Abstract
Abstract
Background
Head circumference is widely used as an indirect indicator of brain growth and cranial capacity; however, its isolated use may lead to imprecise interpretations, particularly in borderline cases of microcephaly and megalencephaly. Complementary screening approaches that remain accessible and non-invasive may therefore be useful, especially in settings with limited access to neuroimaging.
Objective
To develop and evaluate an experimental, non-invasive model for estimating endocranial volume based on a combined cranial metric, termed the Triple-Measure, and to compare its performance with head circumference alone across different age ranges.
Methods
One hundred forensic facial approximations with known cranial scale were analyzed. Head circumference, sagittal arc, and coronal arc were measured on three-dimensional skull models, and their sum was defined as the Triple-Measure. Endocranial volume was obtained through direct segmentation of computed tomography data or by anatomical deformation of donor models. Regression analyses and validation procedures were performed, and the results were contextualized using literature-derived datasets to assess compatibility with established population parameters.
Results
The Triple-Measure showed a stronger correlation with endocranial volume (R = 0.83; R² = 0.69) than head circumference alone (R = 0.76; R² = 0.57), a difference confirmed by an F-test (F ≈ 17.03, p
Conclusions
The Triple-Measure may provide a more informative anthropometric proxy for endocranial volume than head circumference alone while remaining non-invasive and accessible. Given its exploratory nature, the method is best interpreted as a complementary screening approach intended to support clinical decision-making and to indicate when further imaging evaluation may be warranted. Additional studies with larger clinical datasets are recommended to refine its applicability across populations.
Highlights
Triple-measure shows improved association with endocranial volume compared to head circumference
Proposed as a non-invasive, low-cost screening approach for micro- and megalencephaly
Analog lookup table and digital calculator developed for exploratory and practical use
Framework extended across neonatal, pediatric, and adult age groups using integrated datasets