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Akira Shinohara, Yisui Xia, Xingzhi Xu, Shunichi Takeda
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Fast and Efficient DNA Replication With Purified Human Proteins
10.1038/s41586-022-04759-1 · 2022
Regulated Eukaryotic DNA Replication Origin Firing With Purified Proteins
10.1038/nature14285 · 2015
How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication
10.1016/j.molcel.2016.11.017 · 2017
Pif1‐Family Helicases Support Fork Convergence During DNA Replication Termination in Eukaryotes
10.1016/j.molcel.2019.01.040 · 2019
The CMG DNA Helicase and the Core Replisome
10.1016/j.sbi.2023.102612 · 2023
The Initiation of Eukaryotic DNA Replication
10.1146/annurev-biochem-072321-110228 · 2022
Dynamic Molecular Combing: Stretching the Whole human Genome for High‐Resolution Studies
10.1126/science.277.5331.1518 · 1997
Replicon Clusters are Stable Units of Chromosome Structure: Evidence That Nuclear Organization Contributes to the Efficient Activation and Propagation of S Phase in human Cells
10.1083/jcb.140.6.1285 · 1998
DNA Fiber Assay for the Analysis of DNA Replication Progression in Human Pluripotent Stem Cells
10.1002/cpsc.115 · 2020
Monitoring and Quantifying Replication Fork Dynamics With High‐Throughput Methods
10.1038/s42003-024-06412-1 · 2024
Quantifying DNA Replication Speeds in Single Cells by scEdU‐seq
10.1038/s41592-024-02308-4 · 2024
Effects of Acute Versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability
10.1158/0008-5472.can-09-2715 · 2010
dNTP Pools Determine Fork Progression and Origin Usage Under Replication Stress
10.1038/emboj.2011.470 · 2012
Redox‐Sensitive Alteration of Replisome Architecture Safeguards Genome Integrity
10.1126/science.aao3172 · 2017
cGAS Suppresses Genomic Instability as a Decelerator of Replication Forks
10.1126/sciadv.abb8941 · 2020
Developmental Differences in Genome Replication Program and Origin Activation
10.1093/nar/gkaa1124 · 2020
Genome‐Wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2
10.1016/j.molcel.2018.03.036 · 2018
Sources, Resolution and Physiological Relevance of R‐Loops and RNA‐DNA Hybrids
10.1038/s41580-022-00474-x · 2022
The DNA Replication Program is Altered at the FMR1 Locus in Fragile X Embryonic Stem Cells
10.1016/j.molcel.2013.10.029 · 2014
The Mechanism of Replication Stalling and Recovery Within Repetitive DNA
10.1038/s41467-022-31657-x · 2022
Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells
10.1016/j.molcel.2024.04.004 · 2024
Uracil‐induced Replication Stress Drives Mutations, Genome Instability, Anti‐Cancer Treatment Efficacy, and Resistance
10.1016/j.molcel.2025.04.015 · 2025
CDK‐Independent and PCNA‐Dependent Functions of p21 in DNA Replication
10.3390/genes11060593 · 2020
Endogenous p21 Levels Protect Genomic Stability by Suppressing both Excess and Restrained Nascent DNA Syntheses
10.1126/sciadv.adw4618 · 2025
SLFN11 Blocks Stressed Replication Forks Independently of ATR
10.1016/j.molcel.2018.01.012 · 2018
Chk1 promotes Replication Fork Progression by Controlling Replication Initiation
10.1073/pnas.1005031107 · 2010
A High‐Resolution, Nanopore‐Based Artificial Intelligence Assay for DNA Replication Stress in Human Cancer Cells
10.1038/s41467-025-63168-w · 2025
High Speed of Fork Progression Induces DNA Replication Stress and Genomic Instability
10.1038/s41586-018-0261-5 · 2018
ATR‐Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross‐Links
10.1016/j.celrep.2018.08.019 · 2018
PCNA‐Mediated Stabilization of E3 Ligase RFWD3 at the Replication Fork is Essential for DNA Replication
10.1073/pnas.1814521115 · 2018
USP7 is a SUMO Deubiquitinase Essential for DNA Replication
10.1038/nsmb.3185 · 2016
SUMO2 conjugation of PCNA Facilitates Chromatin Remodeling to Resolve Transcription‐Replication Conflicts
10.1038/s41467-018-05236-y · 2018
MCM5 UFMylation Regulates Replication Origin Firing and Fork Progression
2025
Interferon‐Stimulated Gene 15 Accelerates Replication Fork Progression Inducing Chromosomal Breakage
10.1083/jcb.202002175 · 2020
Interferon Restores Replication Fork Stability and Cell Viability in BRCA‐defective Cells via ISG15
10.1038/s41467-023-41801-w · 2023
PARP1 Auto‐Modification Promotes Faithful Okazaki Fragment Processing and Limits Replication Fork Speed
10.1016/j.molcel.2025.09.006 · 2025
Dynamic De Novo Heterochromatin Assembly and Disassembly at Replication Forks Ensures Fork Stability
10.1038/s41556-023-01167-z · 2023
Embryonic Genome Instability Upon DNA Replication Timing Program Emergence
10.1038/s41586-024-07841-y · 2024
DNA Replication in Early Mammalian Embryos is Patterned, Predisposing Lamina‐Associated Regions to Fragility
10.1038/s41467-024-49565-7 · 2024
Spi‐1/PU.1 Oncogene Accelerates DNA Replication Fork Elongation and Promotes Genetic Instability in the Absence of DNA Breakage
10.1158/0008-5472.can-09-4691 · 2010
Stems Cells and the Pathways to Aging and Cancer
10.1016/j.cell.2008.01.036 · doi-reference
Maintaining Genome Stability in the Nervous System
10.1038/nn.3537 · doi-reference
Mutations in ORC1, Encoding the Largest Subunit of the Origin Recognition Complex, Cause Microcephalic Primordial Dwarfism Resembling Meier‐Gorlin Syndrome
10.1038/ng.776 · doi-reference
A Mouse Model of ATR‐Seckel Shows Embryonic Replicative Stress and Accelerated Aging
10.1038/ng.420 · doi-reference
The Expanding Genetic and Clinical Landscape Associated With Meier‐Gorlin Syndrome
10.1038/s41431-023-01359-z · doi-reference
Mechanisms and Pathways of Growth Failure in Primordial Dwarfism
10.1101/gad.169037 · doi-reference
Biallelic UFM1 and UFC1 Mutations Expand the Essential Role of Ufmylation in Brain Development
10.1093/brain/awy135 · doi-reference
UFM1 Founder Mutation in the Roma Population Causes Recessive Variant of H‐ABC
10.1212/wnl.0000000000004578 · doi-reference
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin‐Like Modifier Pathway to Severe Infantile‐Onset Encephalopathy
10.1016/j.ajhg.2016.06.020 · doi-reference
UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar Ataxia
10.1371/journal.pone.0149039 · doi-reference
Biallelic Variants in UBA5 Reveal That Disruption of the UFM1 Cascade Can Result in Early‐Onset Encephalopathy
10.1016/j.ajhg.2016.06.030 · doi-reference
The Embryonic Origins of Erythropoiesis in Mammals
10.1182/blood-2012-01-153486 · doi-reference
RCAD/Ufl1, a Ufm1 E3 Ligase, is Essential for Hematopoietic Stem Cell Function and Murine Hematopoiesis
10.1038/cdd.2015.51 · doi-reference
The Ufm1‐Activating Enzyme Uba5 is Indispensable for Erythroid Differentiation in Mice
10.1038/ncomms1182 · doi-reference
Mutations in DONSON Disrupt Replication Fork Stability and Cause Microcephalic Dwarfism
10.1038/ng.3790 · doi-reference
DNSN‐1 Recruits GINS for CMG Helicase Assembly During DNA Replication Initiation in Caenorhabditis elegans
10.1126/science.adi4932 · doi-reference
In Silico Protein Interaction Screening Uncovers DONSON's Role in Replication Initiation
10.1126/science.adi3448 · doi-reference
Inherited GINS1 Deficiency Underlies Growth Retardation Along With Neutropenia and NK Cell Deficiency
10.1172/jci90727 · doi-reference
Congenital Diseases of DNA Replication: Clinical Phenotypes and Molecular Mechanisms
10.3390/ijms22020911 · doi-reference
CryoEM Structures of Human CMG‐ATPgammaS‐DNA and CMG‐AND‐1 Complexes
10.1093/nar/gkaa429 · doi-reference
Structure of a Human Replisome Shows the Organisation and Interactions of a DNA Replication Machine
10.15252/embj.2021108819 · doi-reference
A Conserved Mechanism for Regulating Replisome Disassembly in Eukaryotes
10.1038/s41586-021-04145-3 · doi-reference
Chemoproteomic Screening of Covalent Ligands Reveals UBA5 as a Novel Pancreatic Cancer Target
10.1021/acschembio.7b00020 · doi-reference
The Present and Future of the Cancer Dependency Map
10.1038/s41568-024-00763-x · doi-reference
Defining a Cancer Dependency Map
10.1016/j.cell.2017.06.010 · doi-reference
Dynamic Recruitment of UFM1‐specific Peptidase 2 to the DNA Double‐Strand Breaks Regulated by WIP1
10.1007/s42764-022-00076-z · doi-reference
MRE11 UFMylation Promotes ATM Activation
10.1093/nar/gkz110 · doi-reference
UFL1 promotes Histone H4 Ufmylation and ATM Activation
10.1038/s41467-019-09175-0 · doi-reference
The Ufmylation Modification of Ribosomal Protein L10 in the Development of Pancreatic Adenocarcinoma
10.1038/s41419-023-05877-y · doi-reference
UFMylation Maintains Tumour Suppressor p53 Stability by Antagonizing Its Ubiquitination
10.1038/s41556-020-0559-z · doi-reference
UFM1 E3 ligase Promotes Recycling of 60S Ribosomal Subunits From the ER
10.1038/s41586-024-07073-0 · doi-reference
The UFM1 E3 Ligase Recognizes and Releases 60S Ribosomes From ER Translocons
10.1038/s41586-024-07093-w · doi-reference
Ufmylation on UFBP1 Alleviates Non‐Alcoholic Fatty Liver Disease by Modulating Hepatic Endoplasmic Reticulum Stress
10.1038/s41419-023-06095-2 · doi-reference
Mechanistic Insights Into the Roles of the UFM1 E3 Ligase Complex in Ufmylation and Ribosome‐Associated Protein Quality Control
10.1126/sciadv.adh3635 · doi-reference
The UFM1 System: Working Principles, Cellular Functions, and Pathophysiology
10.1016/j.molcel.2023.11.034 · doi-reference
Targeting the DNA Repair Defect in BRCA Mutant Cells as a Therapeutic Strategy
10.1038/nature03445 · doi-reference
Specific Killing of BRCA2‐Deficient Tumours With Inhibitors of Poly(ADP‐ribose) Polymerase
10.1038/nature03443 · doi-reference
Deciphering the Fate of Replication‐Induced DNA Double‐Strand Breaks
10.1016/j.molcel.2024.12.006 · doi-reference
Structure and Repair of Replication‐Coupled DNA Breaks
10.1126/science.ado3867 · doi-reference
Fork Pausing Complex Engages Topoisomerases at the Replisome
10.1101/gad.331868.119 · doi-reference