Thyroid hormone transporters and the brain

Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in allan-herndon-dudley syndrome

10.1523/jneurosci.6055-08.2009 · doi-reference

Thyroid hormone transporters MCT8 and OATP1C1 are expressed in projection neurons and interneurons of basal ganglia and motor thalamus in the adult human and macaque brains

10.3390/ijms24119643 · doi-reference

Evidence for a homodimeric structure of human monocarboxylate transporter 8

10.1210/en.2009-0699 · doi-reference

Modeling psychomotor retardation using iPSCs from MCT8-Deficient patients indicates a prominent role for the blood-brain barrier

10.1016/j.stem.2017.04.002 · doi-reference

Estrogen and thyroid hormone receptor interactions: Physiological flexibility by molecular specificity

10.1152/physrev.00014.2002 · doi-reference

Monocarboxylate transporter 8 deficiency: From pathophysiological understanding to therapy development

10.3389/fendo.2021.723750 · doi-reference

Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation

10.1210/en.2008-0430 · doi-reference

Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8

10.1172/jci28253 · doi-reference

Molecular mechanism of thyroxine transport by monocarboxylate transporters

10.1038/s41467-025-59751-w · doi-reference

Structural insights into thyroid hormone transporter MCT8

10.1038/s41467-025-58131-8 · doi-reference

Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: High affinity transporter for thyroxine

10.1074/jbc.m306933200 · doi-reference

Mutated thyroid hormone transporter OATP1C1 associates with severe brain hypometabolism and juvenile neurodegeneration

10.1089/thy.2018.0595 · doi-reference

Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie allan-herndon-dudley syndrome

10.1172/jci.insight.174645 · doi-reference

Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier

10.1210/en.2008-0378 · doi-reference

Thyroid hormone transport by 4F2hc-IU12 heterodimers expressed in xenopus oocytes

10.1677/joe.0.163r005 · doi-reference

Expanding the phenotypic spectrum of allan-herndon-dudley syndrome in patients with SLC16A2 mutations

10.1111/dmcn.14332 · doi-reference

Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter

10.1210/me.2001-0309 · doi-reference

Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis

10.1172/jci70324 · doi-reference

Movement disorders in MCT8 deficiency/allan-herndon-dudley syndrome

10.1016/j.ymgme.2021.12.003 · doi-reference

AAV9-MCT8 delivery at juvenile stage ameliorates neurological and behavioral deficits in a mouse model of MCT8-deficiency

10.1089/thy.2022.0034 · doi-reference

Mutations of the thyroid hormone transporter MCT8 cause prenatal brain damage and persistent hypomyelination

10.1210/jc.2014-2162 · doi-reference

Thyroid hormone availability in the human fetal brain: Novel entry pathways and role of radial glia

10.1007/s00429-019-01896-8 · doi-reference

Characterization of thyroid hormone transport in synaptosomes from rat brain

10.1016/0303-7207(89)90213-x · doi-reference

Adeno associated virus 9-Based gene therapy delivers a functional monocarboxylate transporter 8, improving thyroid hormone availability to the brain of Mct8-deficient mice

10.1089/thy.2016.0060 · doi-reference

Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine

10.1039/b926588k · doi-reference

Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability

10.1210/edrv.22.4.0435 · doi-reference

The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain

10.1073/pnas.94.19.10391 · doi-reference

Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration

10.1038/s41467-025-56628-w · doi-reference

MCT8 deficiency: The road to therapies for a rare disease

10.3389/fnins.2020.00380 · doi-reference

Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1

10.1016/j.cell.2025.06.032 · doi-reference

Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10

10.1210/me.2007-0112 · doi-reference

Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation

10.1016/s0140-6736(04)17226-7 · doi-reference

Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter

10.1074/jbc.m300909200 · doi-reference

Thyroid hormone transport by the heterodimeric human system L amino acid transporter

10.1210/endo.142.10.8418 · doi-reference

Tissue-specific patterns of changes in 3,5,3'-triiodo-L-thyronine concentrations in thyroidectomized rats infused with increasing doses of the hormone. which are the regulatory mechanisms?

10.1016/s0300-9084(99)80095-9 · doi-reference

Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice

10.1210/en.2006-0390 · doi-reference

A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene

10.1086/380999 · doi-reference

Estradiol and the development of the cerebral cortex: An unexpected role?

10.3389/fnins.2018.00245 · doi-reference

An analysis of the sources and quantity of 3,5,3'-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum

10.1210/endo-110-2-367 · doi-reference

MCT8 expression in human fetal cerebral cortex is reduced in severe intrauterine growth restriction

10.1530/joe-13-0400 · doi-reference