Unraveling protein function with structural biology approaches

Advances in integrative structural biology: towards understanding protein complexes in their cellular context

10.1016/j.csbj.2020.11.052 · doi-reference

Targeting p53–MDM2 interaction by small-molecule inhibitors: learning from MDM2 inhibitors in clinical trials

10.1186/s13045-022-01314-3 · doi-reference

TROSY-based NMR experiments for NMR studies of large biomolecules

10.1016/j.pnmrs.2007.10.001 · doi-reference

AlphaFold2 and its applications in the fields of biology and medicine

10.1038/s41392-023-01381-z · doi-reference

Recent technical advances in sample preparation for single-particle Cryo-EM

10.3389/fmolb.2022.892459 · doi-reference

Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography

10.1038/s41557-023-01329-4 · doi-reference

Conformational basis of g protein-coupled receptor signaling versatility

10.1016/j.tcb.2020.06.002 · doi-reference

High-throughput crystallization pipeline at the crystallography core facility of the institut pasteur

10.3390/molecules24244451 · doi-reference

Integrative structure modeling with the integrative modeling platform

10.1002/pro.3311 · doi-reference

Design, synthesis and biological evaluation of potent epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors against resistance mutation for lung cancer treatment

10.1016/j.bioorg.2023.107004 · doi-reference

AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

10.1093/nar/gkab1061 · doi-reference

Classification of intrinsically disordered regions and proteins

10.1021/cr400525m · doi-reference

α-Synuclein aggregation is triggered by oligomeric amyloid-β 42 via heterogeneous primary nucleation

10.1021/jacs.3c03212 · doi-reference

Irreversible alterations in the hemoglobin structure affect oxygen binding in human packed red blood cells

10.1016/j.bbamcr.2020.118803 · doi-reference

Single-molecule dynamic structural biology with vertically arranged DNA on a fluorescence microscope

10.1038/s41592-024-02498-x · doi-reference

Cell–cell communication: new insights and clinical implications

10.1038/s41392-024-01888-z · doi-reference

Utilizing molecular dynamics simulations, machine learning, Cryo-EM, and NMR spectroscopy to predict and validate protein dynamics

10.3390/ijms25179725 · doi-reference

Applications of molecular dynamics simulation in protein study

10.3390/membranes12090844 · doi-reference

Hybrid methods for combined experimental and computational determination of protein structure

10.1063/5.0026025 · doi-reference

Structural variants in the Epb41l4a locus: TAD disruption and Nrep gene misregulation as hypothetical drivers of neurodevelopmental outcomes

10.1038/s41598-024-52545-y · doi-reference

Small angle X-ray scattering and cross-linking for data assisted protein structure prediction in CASP 12 with prospects for improved accuracy

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Applications of NMR and computational methodologies to study protein dynamics

10.1016/j.abb.2017.05.002 · doi-reference

Hybrid computational methods combining experimental information with molecular dynamics

10.1016/j.sbi.2023.102609 · doi-reference

Protein structure prediction via deep learning: an in-depth review

10.3389/fphar.2025.1498662 · doi-reference

Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis

10.1021/acs.chemrev.8b00532 · doi-reference

Dynamics-based drug discovery by time-resolved cryo-EM

10.1016/j.sbi.2025.103001 · doi-reference

Experimental methods to study the structure and dynamics of intrinsically disordered regions in proteins

10.1016/j.crstbi.2024.100138 · doi-reference

Combined thermodynamic and time-resolved structural analysis of interactions between AP2 and biomimetic plasma membranes provides insights into clathrin-mediated endocytosis

10.1038/s42003-025-08597-5 · doi-reference

Structural dynamics: review of time-resolved cryo-EM

10.1107/s2059798322006155 · doi-reference

Impact of novel detergents on membrane protein studies

10.1016/j.chempr.2022.02.007 · doi-reference

Mathematical models describing oxygen binding by hemoglobin

10.1007/s12551-023-01110-4 · doi-reference

AlphaFold 2 and NMR spectroscopy: partners to understand protein structure, Dynamics and Function

10.3389/fmolb.2022.906437 · doi-reference

Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy

10.1113/jp274888 · doi-reference

Highly accurate protein structure prediction with AlphaFold

10.1038/s41586-021-03819-2 · doi-reference

Accelerators for classical molecular dynamics simulations of biomolecules

10.1021/acs.jctc.1c01214 · doi-reference

Role of receptor tyrosine kinases mediated signal transduction pathways in tumor growth and angiogenesis—New insight and futuristic vision

10.1016/j.ijbiomac.2021.03.075 · doi-reference

Structural biology of RNA and protein-RNA complexes after AlphaFold3

10.1002/cbic.202401047 · doi-reference

Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance

10.1021/jm060561m · doi-reference

Insights into protein–ligand interactions: mechanisms, models, and methods

10.3390/ijms17020144 · doi-reference

Cryo-EM: the resolution revolution and drug discovery

10.1177/2472555220960401 · doi-reference