Abstract
Eun Ko, Fathima A. Mohamed, Stephanie Y. Rhee, Rocio Amaro Marquez, Joanna Ly, Ethan G. Aguilar, Haley Melin, Peter T. Sage, Tanner Schumacher, Conor Ronayne, Angela Panoskaltsis-Mortari, Megan Riddle, Mark Osborn, Govindarajan Thangavelu, Peter A. Crawford, Roddy S. O’Connor, Michael C. Zaiken, Keli L. Hippen, Leslie S. Kean, Jeffrey C. Rathmell, Jason W. Locasale, Venkatram Mereddy, Bruce R. Blazar
Abstract
Authors
Institutions
No ROR-resolved institution is linked to this work yet.
Provenance
crossref
Confidence 100%
unpaywall
Confidence 95%
datacite
Confidence 0%
No local reference links have been materialized yet.
No local citing links have been materialized yet.
Indications for Autologous and Allogeneic Hematopoietic Cell Transplantation: Guidelines from the American Society for Blood and Marrow Transplantation
10.1016/j.bbmt.2015.07.032 · 2015
Immunobiology of allogeneic hematopoietic stem cell transplantation
10.1146/annurev.immunol.25.022106.141606 · 2007
Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets
10.1056/nejmra1703472 · 2017
The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease
10.1016/j.bbmt.2016.09.023 · 2017
Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans
10.1182/blood-2014-03-562231 · 2014
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans
10.1182/blood-2011-07-364414 · 2012
FDA-approved therapies for chronic GVHD
10.1182/blood.2024026633 · 2025
Clinical response to belumosudil in bronchiolitis obliterans syndrome: a combined analysis from 2 prospective trials
10.1182/bloodadvances.2022008095 · 2022
Axatilimab in Patients With Lung Chronic Graft-versus-Host Disease and Related Bronchiolitis Obliterans Syndrome
2025
Metabolic pathways in immune cell activation and quiescence
10.1016/j.immuni.2013.04.005 · 2013
Metabolic adaptations of tissue-resident immune cells
10.1038/s41590-019-0407-0 · 2019
The CD28 signaling pathway regulates glucose metabolism
10.1016/s1074-7613(02)00323-0 · 2002
Metabolic regulation of T lymphocytes
10.1146/annurev-immunol-032712-095956 · 2013
Metabolic Adaptations of CD4+ T Cells in Inflammatory Disease
10.3389/fimmu.2018.00540 · 2018
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
2011
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
10.1126/scisignal.aab2610 · 2015
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
10.1016/j.cell.2018.10.001 · 2018
Fatty acid synthase regulates the pathogenicity of Th17 cells
10.1189/jlb.3ab0417-159rr · 2017
Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis
10.1172/jci125917 · 2019
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells
10.1016/j.immuni.2019.05.014 · 2019
Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states
10.1038/s41467-023-43427-4 · 2023
T Follicular Helper Cell Biology: A Decade of Discovery and Diseases
10.1016/j.immuni.2019.04.011 · 2019
Follicular helper CD4 T cells (TFH)
10.1146/annurev-immunol-031210-101400 · 2011
Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination
2016
Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity
10.1073/pnas.1811702116 · 2019
Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis
10.3389/fimmu.2018.01973 · 2018
Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
10.1038/s41467-018-06686-0 · 2018
HIF1α-Dependent Metabolic Signals Control the Differentiation of Follicular Helper T Cells
10.3390/cells8111450 · 2019
Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo
10.1371/journal.pone.0023205 · 2011
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function
10.1016/j.cmet.2014.05.004 · 2014
A new murine model for bronchiolitis obliterans post-bone marrow transplant
10.1164/rccm.200702-335oc · 2007
In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses
10.1007/978-1-4939-2498-1_13 · 2015
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
10.1016/j.immuni.2012.10.020 · 2013
Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma
10.1186/s12964-020-00539-4 · 2020
The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations
10.1038/s41598-018-24676-6 · 2018
Development of novel mitochondrial pyruvate carrier inhibitors for breast cancer treatment
10.1016/j.jbc.2025.110486 · 2025
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
10.1038/ni.2496 · 2013
Abnormal T cell-dependent B-cell responses in SCID mice receiving allogeneic bone marrow in utero. Severe combined immune deficiency
10.1182/blood-2002-04-1232 · 2002
Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease
10.1182/blood-2018-03-839993 · 2019
Bcl-6 directly represses the gene program of the glycolysis pathway
10.1038/ni.2985 · 2014
Side effect profile of pharmacologic therapies for liver fibrosis in nonalcoholic fatty liver disease: a systematic review and network meta-analysis
10.1097/meg.0000000000002471 · doi-reference
Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study
10.1016/j.jhep.2019.10.023 · doi-reference
Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration
10.1186/s13024-018-0260-x · doi-reference
Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism
10.1182/blood-2015-10-678706 · doi-reference
Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation
10.1172/jci82587 · doi-reference
Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer
10.1158/1535-7163.mct-13-0097 · doi-reference
mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation
10.1016/j.immuni.2016.08.017 · doi-reference
MicroRNA-31 regulates T-cell metabolism via HIF1α and promotes chronic GVHD pathogenesis in mice
10.1182/bloodadvances.2021005103 · doi-reference
Fueling immunity: insights into metabolism and lymphocyte function
10.1126/science.1242454 · doi-reference
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
10.1016/j.cmet.2016.12.018 · doi-reference
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
10.1172/jci76012 · doi-reference
Revving the engine: signal transduction fuels T cell activation
10.1016/j.immuni.2007.07.008 · doi-reference
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses
10.1038/s44318-025-00414-3 · doi-reference
Chronic graft-versus-host disease: biological insights from preclinical and clinical studies
10.1182/blood-2016-06-686618 · doi-reference
The relationship between CD4+ T cell glycolysis and their functions
10.1016/j.tem.2023.03.006 · doi-reference
Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system
10.1038/nature19334 · doi-reference
Normalization of CD4+ T cell metabolism reverses lupus
10.1126/scitranslmed.aaa0835 · doi-reference
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells
10.1016/j.immuni.2015.08.017 · doi-reference
The fat and the furious: fatty acids fuel hyperproliferative germinal center B cells
10.1038/s41423-020-0446-3 · doi-reference
Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis
10.1038/s41590-020-0598-4 · doi-reference
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function
10.1038/ni.3578 · doi-reference
The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis
10.3390/cancers13071488 · doi-reference
Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet
10.1186/1743-7075-5-33 · doi-reference
T follicular regulatory cells in the regulation of B cell responses
10.1016/j.it.2015.05.005 · doi-reference