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Privacy-aware community infrastructureKatharina Held
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10.1038/nrd2757 · 2009
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10.1152/physrev.00005.2019 · 2019
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10.1113/jp270935 · 2016
Mouse TRPA1 function and membrane localization is modulated by direct interactions with cholesterol
10.7554/elife.46084 · 2019
Lipid raft destabilization impairs mouse TRPA1 responses to cold and bacterial lipopolysaccharides
10.3390/ijms21113826 · 2020
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10.1016/j.ceca.2020.102255 · 2020
Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity
10.1038/srep28763 · 2016
The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain
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Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain
10.1073/pnas.1412689111 · 2014
Statin use in prostate Cancer: an update
10.4137/nmi.s38362 · 2016
Statins and colorectal cancer
10.1016/j.cgh.2012.08.037 · 2013
Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis
10.1038/s41598-018-24248-8 · 2018
The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms
10.1186/s40035-018-0110-3 · 2018
The pharmacology of statins
10.1016/j.phrs.2014.03.002 · 2014
The essential role of transient receptor potential vanilloid 1 in simvastatin-induced activation of endothelial nitric oxide synthase and angiogenesis
10.1111/apha.12378 · 2014
Statins activate temperature-gated transient receptor potential ion channels
10.1016/j.ejphar.2025.178206 · 2025
The agonist action of Alkylphenols on TRPA1 relates to their effects on membrane lipid order: implications for TRPA1-mediated Chemosensation
10.3390/ijms22073368 · 2021
TRP channels as sensors of chemically-induced changes in cell membrane mechanical properties
10.3390/ijms20020371 · 2019
Differential interactions of bacterial lipopolysaccharides with lipid membranes: implications for TRPA1-mediated chemosensation
10.1038/s41598-018-30534-2 · 2018
Quantitation of lipid phases in phospholipid vesicles by the generalized polarization of Laurdan fluorescence
10.1016/s0006-3495(91)82041-0 · 1991
Use of laurdan fluorescence intensity and polarization to distinguish between changes in membrane fluidity and phospholipid order
10.1016/s0005-2736(02)00514-x · 2002
The increase in bilayer fluidity of rat liver plasma membranes achieved by the local anesthetic benzyl alcohol affects the activity of intrinsic membrane enzymes
10.1016/s0021-9258(19)85523-0 · 1980
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
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TRP channel activation by reversible covalent modification
10.1073/pnas.0609598103 · 2006
Elucidation of the binding mode of organic polysulfides on the human TRPA1 receptor
2023
Ligustilide: a novel TRPA1 modulator
10.1007/s00424-011-1021-7 · 2011
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels
10.1523/jneurosci.2772-08.2008 · 2008
Activation of Drosophila melanogaster TRPA1 isoforms by citronellal and menthol
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Structure of the TRPA1 ion channel suggests regulatory mechanisms
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Identification of the TRPA1 cannabinoid-binding site
10.1016/j.phrs.2024.107444 · 2024
Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein
10.1074/jbc.m114.586891 · 2014
Evidence for the role of lipid rafts and sphingomyelin in Ca2+−gating of transient receptor potential channels in trigeminal sensory neurons and peripheral nerve terminals
10.1016/j.phrs.2015.07.028 · 2015
Cyclodextrin derivatives decrease transient receptor potential vanilloid 1 and ankyrin 1 ion channel activation via altering the surrounding membrane microenvironment by cholesterol depletion
10.3389/fcell.2024.1334130 · 2024
Cyclodextrins inhibit TRPV1 and TRPA1 activation-induced nociception via cholesterol depletion
10.1016/j.jlr.2025.100844 · 2025
Statins-from fungi to pharmacy
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To flourish or perish: evolutionary TRiPs into the sensory biology of plant-herbivore interactions
10.1007/s00424-018-2205-1 · 2019
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10.1111/j.1365-2125.2011.03907.x · 2011
Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
1996
Pharmacokinetics of high-dose simvastatin in refractory and relapsed chronic lymphocytic leukemia patients
10.1007/s00280-013-2326-3 · 2013
TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine
10.1074/jbc.m609600200 · 2007
Differentiation of 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors by their relative lipophilicity
10.1211/146080899128734820 · doi-reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · doi-reference
Alterations in membrane fluidity and dynamics in experimental colon cancer and its chemoprevention by diclofenac
10.1007/s11010-010-0441-6 · doi-reference
A new generation of Ca2+ indicators with greatly improved fluorescence properties
10.1016/s0021-9258(19)83641-4 · doi-reference
Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors
10.1002/emmm.201100134 · doi-reference
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
10.1016/s0092-8674(03)00158-2 · doi-reference
Trp12, a novel Trp related protein from kidney
10.1016/s0014-5793(00)02212-2 · doi-reference
The role of structure and biophysical properties in the pleiotropic effects of statins
10.3390/ijms21228745 · doi-reference
Bimodal action of menthol on the transient receptor potential channel TRPA1
10.1523/jneurosci.2221-07.2007 · doi-reference
Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential Ankyrin 1 (TRPA1) for activation by Eudesmol, an oxygenized Sesquiterpene in hop essential oil
10.1074/jbc.m114.600932 · doi-reference
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10.1016/j.neuron.2020.10.014 · doi-reference
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10.1084/jem.20201637 · doi-reference
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
10.1038/s41586-020-2480-9 · doi-reference
Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner
10.1007/s00424-011-1069-4 · doi-reference