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Breast Cancer treatment: a review
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Heterogeneity in breast cancer
10.1172/jci60534 · 2011
Molecular portraits of human breast tumours
10.1038/35021093 · 2000
Fundamentals of cancer metabolism
10.1126/sciadv.1600200 · 2016
Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate
10.1016/j.ccr.2012.02.014 · 2012
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10.1126/science.1160809 · 2009
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10.1038/nchembio.1712 · 2015
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The multifaceted roles of fatty acid synthesis in cancer
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Cancer metabolism: fatty acid oxidation in the limelight
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Metabolic interactions in the tumor microenvironment
10.1016/j.tcb.2017.06.003 · 2017
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10.1016/j.cmet.2007.10.002 · 2008
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Inhibitory effect of tumor cell-derived lactic acid on human T cells
10.1182/blood-2006-07-035972 · 2007
LDHA-associated lactic acid production blunts tumor Immunosurveillance by T and NK cells
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Drug resistance in cancer: molecular mechanisms and emerging treatment strategies
10.1186/s43556-025-00352-w · doi-reference
OXPHOS-targeting drugs in oncology: new perspectives
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