Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling
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IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice
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Fibroblast growth factor 21 inhibited ischemic arrhythmias via targeting miR-143/EGR1 axis
10.1007/s00395-019-0768-4 · doi-reference
Cardiac fibroblast-derived IGFBP6 orchestrates cardiac remodeling by coupling the EGR1-MFAP4 axis
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Ferroptosis as a novel therapeutic target for cardiovascular disease
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STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation
10.1038/s41392-025-02216-9 · doi-reference
Single-Cell Multi-Omics Identifies Specialized Cytotoxic and Migratory CD8(+) Effector T Cells in Acute Myocarditis
10.1161/circulationaha.125.073836 · doi-reference
ISCU-p53 axis orchestrates macrophage polarization to dictate immunotherapy response in esophageal squamous cell carcinoma
10.1038/s41419-025-07787-7 · doi-reference
A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells
10.1038/sj.cdd.4402029 · doi-reference
Egr1 mediates retinal vascular dysfunction in diabetes mellitus via promoting p53 transcription
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The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin
10.1038/sj.cgt.7700896 · doi-reference
Irf1- and Egr1-activated transcription plays a key role in macrophage polarization: a multiomics sequencing study with partial validation
10.1016/j.intimp.2021.108072 · doi-reference
miR-30e-3p Promotes Cardiomyocyte Autophagy and Inhibits Apoptosis via Regulating Egr-1 during Ischemia/Hypoxia
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JNK-dependent phosphorylation and nuclear translocation of EGR-1 promotes cardiomyocyte apoptosis
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Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53
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Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence
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Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis
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Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network
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Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice
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Ferroptosis as a p53-mediated activity during tumour suppression
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STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway
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Tumor-Associated Antigen xCT and mutant-p53 as Molecular Targets for New Combinatorial Antitumor strategies
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TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation
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Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation
10.1016/j.redox.2024.103066 · doi-reference
Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα
10.1080/13880209.2023.2212700 · doi-reference
Interferon-γ induces salivary gland epithelial cell ferroptosis in Sjogren's syndrome via JAK/STAT1-mediated inhibition of system Xc−
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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine responses
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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue damage, and Mortality in SARS-CoV-2 Infection and Cytokine shock Syndromes
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Distinct Inflammatory responses of hiPSC-derived Endothelial Cells and Cardiomyocytes to Cytokines involved in Immune Checkpoint Inhibitor-Associated Myocarditis
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Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis
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Risk Factors for Immune Checkpoint Inhibitor-Mediated Cardiovascular Toxicities
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The good (Tumor Killing) and the bad (Cardiovascular Complications) of Immunologic Checkpoint Inhibitors
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Atherosclerosis with Immune Checkpoint Inhibitor Therapy: evidence, Diagnosis, and Management: JACC: CardioOncology State-of-the-Art Review
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Immune checkpoint inhibitors: Unravelling atherosclerotic cardiovascular risk
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