Injectable ECM-mimetic dynamic Schiff-base hydrogels deliver 5-aminosalicylic acid for immunomodulatory and alleviation of ferroptosis-associated injury of intervertebral disc degeneration

A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail

10.1097/brs.0b013e31817c64a9 · doi-reference

ISSLS PRIZE IN BASIC SCIENCE 2018: Growth differentiation factor-6 attenuated pro-inflammatory molecular changes in the rabbit anular-puncture model and degenerated disc-induced pain generation in the rat xenograft radiculopathy model

10.1007/s00586-018-5488-1 · doi-reference

Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently

10.1007/s00586-010-1473-z · doi-reference

Hydrolytic Stability of Hydrazones and Oximes

10.1002/anie.200802651 · doi-reference

Slow depressurization following intradiscal injection leads to injectate leakage in a large animal model

10.1002/jsp2.1061 · doi-reference

RSL3 Drives Ferroptosis through NF-κB Pathway Activation and GPX4 Depletion in Glioblastoma

10.1155/2021/2915019 · doi-reference

5-Aminosalicylic acid inhibits inflammatory responses by suppressing JNK and p38 activity in murine macrophages

10.1080/08923973.2016.1274997 · doi-reference

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

10.1016/j.immuni.2014.06.008 · doi-reference

Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway

10.1038/s12276-024-01168-4 · doi-reference

Secreted Factors From Intervertebral Disc Cells and Infiltrating Macrophages Promote Degenerated Intervertebral Disc Catabolism

10.1097/brs.0000000000002953 · doi-reference

Glutaminolysis and Transferrin Regulate Ferroptosis

10.1016/j.molcel.2015.06.011 · doi-reference

Forkhead box O3 attenuates osteoarthritis by suppressing ferroptosis through inactivation of NF-κB/MAPK signaling

10.1016/j.jot.2023.02.005 · doi-reference

Ferroptosis: mechanisms, biology and role in disease

10.1038/s41580-020-00324-8 · doi-reference

Regulation of Ferroptotic Cancer Cell Death by GPX4

10.1016/j.cell.2013.12.010 · doi-reference

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

10.1016/j.cell.2012.03.042 · doi-reference

Injectable oxidized hyaluronic acid/adipic acid dihydrazide hydrogel for nucleus pulposus regeneration

10.1016/j.actbio.2010.02.037 · doi-reference

Dynamic covalent hydrogels as biomaterials to mimic the viscoelasticity of soft tissues

10.1016/j.pmatsci.2020.100738 · doi-reference

Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target

10.1038/srep37360 · doi-reference

Biology of Intervertebral Disc Aging and Degeneration: Involvement of the Extracellular Matrix

10.1097/01.brs.0000146101.53784.b1 · doi-reference

Designing hydrogels for controlled drug delivery

10.1038/natrevmats.2016.71 · doi-reference

Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture: Laboratory investigation

10.3171/2009.2.spine08925 · doi-reference

The Leakage Pathway and Effect of Needle Gauge on Degree of Disc Injury Post Anular Puncture: A Comparative Study Using Aged Human and Adolescent Porcine Discs

10.1097/brs.0b013e31811ec282 · doi-reference

Solute Transport in Intervertebral Disc

10.1111/j.1749-6632.2008.04075.x · doi-reference

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ

10.1084/jem.20041948 · doi-reference

Inhibition of Interleukin-1-stimulated NF-κB RelA/p65 Phosphorylation by Mesalamine Is Accompanied by Decreased Transcriptional Activity

10.1074/jbc.274.37.26448 · doi-reference

AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis

10.1053/j.gastro.2018.12.009 · doi-reference

Macrophage-derived inflammatory cytokines regulate growth factors and pain-related molecules in mice with intervertebral disc injury

10.1002/jor.23888 · doi-reference

Polarization of infiltrating macrophages in the outer annulus fibrosus layer associated with the process of intervertebral disc degeneration and neural ingrowth in the human cervical spine

10.1016/j.spinee.2021.12.005 · doi-reference

Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration

10.1016/j.spinee.2017.09.018 · doi-reference

Tumor necrosis factor α– and interleukin-1β–dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1

10.1002/art.37819 · doi-reference

Role of cytokines in intervertebral disc degeneration: pain and disc content

10.1038/nrrheum.2013.160 · doi-reference

Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis

10.1002/jcp.30039 · doi-reference

The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance

10.1111/cpr.12779 · doi-reference

Mitochondrial quality control in intervertebral disc degeneration

10.1038/s12276-021-00650-7 · doi-reference

PPARgamma-Axl axis ameliorates intervertebral disc degeneration by activating PI3K/AKT-mediated autophagy to suppress ferroptosis

10.1186/s11658-025-00802-x · doi-reference

UCHL3 drives ferroptosis in nucleus pulposus cells by deubiquitinating HMGB1 to activate NCOA4-mediated ferritinophagy

10.1080/15548627.2026.2684463 · doi-reference

An SSK1-loaded decellularized annulus fibrosus matrix-based PD hydrogel alleviates intervertebral disc degeneration through modulation of NF-κB signaling and ferroptosis

10.1016/j.jot.2026.101168 · doi-reference

Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration

10.1016/j.joca.2021.06.010 · doi-reference

Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair

10.1038/s41467-025-66116-w · doi-reference

Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration

10.1016/j.celrep.2024.114342 · doi-reference