Abstract
Tariq Aziz, Rafaqat Hussain, Hina Sarfraz, Uzam Azam, Muhammad Mazhar Asjad, Ammena Y. Binsaleh, Nawal Al-Hoshani, Mariam Mojally
Abstract
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Unresolved referenced work
2023
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10.1016/j.imu.2024.101486 · 2024
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10.21608/sjsci.2026.469702.1350 · 2026
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10.1080/16583655.2024.2350087 · 2024
Synthesis and structural elucidation for new pyrano thiazole complexes: biological screening and effects on DNA through in-vitro and in-silico approaches
10.1016/j.molliq.2021.115844 · 2021
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2026
No additional external references are available.