Abstract
No public abstract is available from the verified source records.
Li-Hua Liu, Yucheng Hu, Xianhong Zhang, Shuqi Wang, Ao Jiang
Abstract
Authors
Institutions
No ROR-resolved institution is linked to this work yet.
Provenance
crossref
Confidence 100%
pubmed
Confidence 98%
unpaywall
Confidence 95%
datacite
Confidence 0%
No local reference links have been materialized yet.
No local citing links have been materialized yet.
From self-replication to replicator systems en route to de novo life
10.1038/s41570-020-0196-x · 2020
Inducible directed evolution of complex phenotypes in bacteria
10.1093/nar/gkac094 · 2022
In vivo diversification of target genomic sites using processive base deaminase fusions blocked by dCas9
10.1038/s41467-020-20230-z · 2020
Comparative analysis of deep mutational scanning datasets in enteroviruses A and B identifies functional divergence and therapeutic targets
10.1038/s41559-026-02993-8 · 2026
CADEE: computer-aided directed evolution of enzymes
10.1107/s2052252516018017 · 2017
Chemical production of mutations
10.1038/157302a0 · 1946
Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site
10.1038/s41467-023-42098-5 · 2023
Genomic language models: opportunities and challenges
10.1016/j.tig.2024.11.013 · 2025
An adaptable platform for directed evolution in human cells
10.1021/jacs.8b10937 · 2018
Low-N protein engineering with data-efficient deep learning
10.1038/s41592-021-01100-y · 2021
Functional alignment of protein language models via reinforcement learning
2026
CatPred: a comprehensive framework for deep learning in vitro enzyme kinetic parameters
10.1038/s41467-025-57215-9 · 2025
Accelerating enzyme discovery and engineering with high-throughput screening
10.1039/d4np00031e · 2025
Virus-free continuous directed evolution in human cells using somatic hypermutation
2026
Genome modelling and design across all domains of life with evo 2
10.1038/s41586-026-10176-5 · 2026
Tunable protein degradation in bacteria
10.1038/nbt.3053 · 2014
BRENDA, the ELIXIR core data resource in 2021: new developments and updates
10.1093/nar/gkaa1025 · 2021
Learning protein fitness landscapes with deep mutational scanning data from multiple sources
10.1016/j.cels.2023.07.003 · 2023
Wearable flexible microfluidic sensing technologies
10.1038/s44222-023-00094-w · 2023
Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes
10.1126/science.adn5876 · 2024
Reconstruction, simulation and analysis of enzyme-constrained metabolic models using GECKO toolbox 3.0
10.1038/s41596-023-00931-7 · 2024
Structural dynamics-guided engineering of a riboswitch RNA for evolving c-di-AMP synthases
10.1126/sciadv.adt8165 · 2025
Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae
10.1038/s41467-023-44511-5 · 2024
Sequence display enables large-scale sequence–activity datasets for rapid protein evolution
10.1038/s41587-026-03087-3 · 2026
BartSmiles: generative masked language models for molecular representations
10.1021/acs.jcim.4c00512 · 2024
Selective fluorescent labeling of cellular proteins and its biological applications
10.1039/d4cs00094c · 2024
Accurate top protein variant discovery via low-N pick-and-validate machine learning
10.1016/j.cels.2024.01.002 · 2024
High-throughput optimisation of protein secretion in yeast via an engineered biosensor
10.1016/j.tibtech.2024.11.010 · 2025
A chimeric viral platform for directed evolution in mammalian cells
10.1038/s41467-025-59438-2 · 2025
Polymerase-guided base editing enables in vivo mutagenesis and rapid protein engineering
10.1038/s41467-021-21876-z · 2021
In vivo continuous evolution of genes and pathways in yeast
10.1038/ncomms13051 · 2016
Enzyme specificity prediction using cross-attention graph neural networks
10.1038/s41586-025-09697-2 · 2025
A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike
10.1016/j.cell.2023.02.001 · 2023
Spike deep mutational scanning helps predict success of SARS-CoV-2 clades
10.1038/s41586-024-07636-1 · 2024
Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro kcat measurements
10.1073/pnas.1514240113 · 2016
Directing evolution: the next revolution in drug discovery?
10.1038/nrd.2017.146 · 2017
Accelerated adaptive laboratory evolution: A tool for evolutionary biotechnology
10.1016/j.biotechadv.2025.108741 · 2026
A propeptide-based biosensor for the selective detection of vibrio cholerae using an environment-sensitive fluorophore
10.1016/j.chembiol.2022.09.003 · 2022
The VEGAS platform is unsuitable for mammalian directed evolution
10.1021/acssynbio.2c00460 · 2022
Miniaturizing and modifying natural proteins with Raygun
10.1038/s41586-026-10842-8 · 2026
Engineered geminivirus replicons enable rapid in planta directed evolution
10.1126/science.ady2167 · doi-reference
Rapid and continuous directed evolution in vibrio natriegens utilizing an in vivo hypermutation system
10.1021/acssynbio.5c00936 · doi-reference
Evolved cytidine and adenine base editors with high precision and minimized off-target activity by a continuous directed evolution system in mammalian cells
10.1038/s41467-024-52483-3 · doi-reference
RNA-responsive elements for eukaryotic translational control
10.1038/s41587-021-01068-2 · doi-reference
Molecular evolution by staggered extension process (StEP) in vitro recombination
10.1038/nbt0398-258 · doi-reference
Accurate enzyme specificity constant prediction with iESC
10.1016/j.biortech.2026.134067 · doi-reference
Replication-coupled dual-deaminase mutagenesis (RCDM) enables continuous genomic evolution in Bacillus subtilis
10.1186/s12934-026-03060-4 · doi-reference
Single-round evolution of RNA aptamers with GRAPE-LM
10.1038/s41587-026-03007-5 · doi-reference
Integrating protein language models and automatic biofoundry for enhanced protein evolution
10.1038/s41467-025-56751-8 · doi-reference
Synthetic biology and artificial intelligence in crop improvement
10.1016/j.xplc.2024.101220 · doi-reference
Screening antimicrobial peptides and probiotics using multiple deep learning and directed evolution strategies
10.1016/j.apsb.2024.05.003 · doi-reference
High-throughput screening technology in industrial biotechnology
10.1016/j.tibtech.2020.01.001 · doi-reference
SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution
10.1038/s41564-021-00954-4 · doi-reference
Biosensor-guided indexing of genome evolution for boosting microbial chemical synthesis
10.1016/j.tibtech.2025.12.019 · doi-reference
PRIME, a temperature-guided language model revolutionizes protein engineering
10.1016/j.apsb.2025.04.010 · doi-reference
Genetically encoded biosensors for microbial synthetic biology: from conceptual frameworks to practical applications
10.1016/j.biotechadv.2022.108077 · doi-reference
Enzyme function prediction using contrastive learning
10.1126/science.adf2465 · doi-reference
Machine learning-enabled retrobiosynthesis of molecules
10.1038/s41929-022-00909-w · doi-reference
In vitro continuous protein evolution empowered by machine learning and automation
10.1016/j.cels.2023.04.006 · doi-reference
UniKP: a unified framework for the prediction of enzyme kinetic parameters
10.1038/s41467-023-44113-1 · doi-reference
Hot spots-making directed evolution easier
10.1016/j.biotechadv.2022.107926 · doi-reference
ERNIE-RNA: an RNA language model with structure-enhanced representations
10.1038/s41467-025-64972-0 · doi-reference
An in vivo target mutagenesis system for multiple hosts
10.1016/j.tibtech.2025.04.005 · doi-reference
Emerging markers for antimicrobial resistance monitoring
10.1016/j.cclet.2023.108238 · doi-reference
Plasmid hypermutation using a targeted artificial DNA replisome
10.1126/sciadv.abg8712 · doi-reference
Glycosylase-based base editors for efficient T-to-G and C-to-G editing in mammalian cells
10.1038/s41587-023-02050-w · doi-reference
Directed evolution of microbial communities in fermented foods: strategies, mechanisms, and challenges
10.3390/foods14020216 · doi-reference
Genetic variation reveals the enhanced microbial hyaluronan biosynthesis via atmospheric and room temperature plasma
10.1016/j.carbpol.2023.120809 · doi-reference
Research progress of nanozymes in colorimetric biosensing: classification, activity and application
10.1016/j.cej.2024.150612 · doi-reference
Opportunities and challenges for machine learning-assisted enzyme engineering
10.1021/acscentsci.3c01275 · doi-reference
Advanced strategies in high-throughput droplet screening for enzyme engineering
10.1016/j.bios.2023.115972 · doi-reference
Advances in high-throughput mutation breeding systems integrating atmospheric and room-temperature plasma (ARTP) with droplet-based microfluidics
10.1186/s12934-025-02873-z · doi-reference
A cell-free bacteriophage synthesis system for directed evolution
10.1016/j.tibtech.2024.10.005 · doi-reference
Directed evolution of Escherichia coli Nissle 1917 to utilize allulose as sole carbon source
10.1002/smtd.202301385 · doi-reference
Enzyme-constrained genome-scale modeling resolves growth-production trade-offs in fermentative biohydrogen production
10.1016/j.ese.2026.100706 · doi-reference
Triple base editor catalyzes saturation mutation of adenine, cytidine, and guanine
10.1093/nar/gkaf1423 · doi-reference
Computer-aided understanding and engineering of enzymatic selectivity
10.1016/j.biotechadv.2021.107793 · doi-reference
SABIO-RK: an updated resource for manually curated biochemical reaction kinetics
10.1093/nar/gkx1065 · doi-reference
Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase
10.1126/science.adt5199 · doi-reference
Enhancing prime editor activity by directed protein evolution in yeast
10.1038/s41467-024-46107-z · doi-reference