Computational design of serine hydrolases
10.1126/science.adu2454 · doi-reference
Computational design of sequence-specific DNA-binding proteins
10.1038/s41594-025-01669-4 · doi-reference
Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase
10.1093/nar/gkw1112 · doi-reference
Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects
10.1186/s13059-026-03967-6 · doi-reference
Genome-wide tracking of dCas9-methyltransferase footprints
10.1038/s41467-017-02708-5 · doi-reference
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins
10.1038/s41467-025-63167-x · doi-reference
Requirements for establishment and epigenetic stability of mammalian heterochromatin
10.1016/j.molcel.2025.08.025 · doi-reference
A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbation
10.1038/s41467-026-72227-9 · doi-reference
Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications
10.1038/s41588-024-01706-w · doi-reference
Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape
10.1038/s43587-025-00841-1 · doi-reference
Epigenome editing strategies for the functional annotation of CTCF insulators
10.1038/s41467-019-12166-w · doi-reference
CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny
10.1073/pnas.2300224120 · doi-reference
Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy
10.1093/neuonc/noaf055 · doi-reference
A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels
10.1038/s41591-025-03508-x · doi-reference
Durable and efficient gene silencing in vivo by hit-and-run epigenome editing
10.1038/s41586-024-07087-8 · doi-reference
Editing DNA methylation in the Mammalian genome
10.1016/j.cell.2016.08.056 · doi-reference
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
10.1038/nbt.2726 · doi-reference
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
10.1126/science.ado7082 · doi-reference
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
10.1016/j.cell.2021.03.025 · doi-reference
Inheritable silencing of endogenous genes by hit-and-run targeted epigenetic editing
10.1016/j.cell.2016.09.006 · doi-reference
Precision epigenetic editing: technological advances, enduring challenges, and therapeutic applications
10.1016/j.chembiol.2024.07.007 · doi-reference
Cytosine methylation targetted to pre-determined sequences
10.1038/ng1297-376 · doi-reference
Epigenetic therapies for cancer
10.1056/nejmra1805035 · doi-reference
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
10.15252/embr.202051803 · doi-reference
Understanding the relationship between DNA methylation and histone lysine methylation
10.1016/j.bbagrm.2014.02.007 · doi-reference
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation
10.1074/jbc.m109.089433 · doi-reference
Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
10.1038/nature14176 · doi-reference
DNA methylation pathways and their crosstalk with histone methylation
10.1038/nrm4043 · doi-reference
TET methylcytosine oxidases: new insights from a decade of research
10.1007/s12038-019-9973-4 · doi-reference
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
10.1038/s41392-023-01537-x · doi-reference
TET family dioxygenases and DNA demethylation in stem cells and cancers
10.1038/emm.2017.5 · doi-reference
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation
10.1038/nature06146 · doi-reference
Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease
10.1038/s41467-026-69563-1 · doi-reference
Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin
10.1038/s41594-025-01704-4 · doi-reference
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
10.1038/s41586-020-2747-1 · doi-reference
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
10.1038/s41467-020-17109-4 · doi-reference
DNA methylation and DNA methyltransferases
10.1186/s13072-017-0130-8 · doi-reference
The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
10.1038/nrg.2017.80 · doi-reference
Epigenetic editing: from concept to clinic
10.1038/s41573-025-01323-0 · doi-reference
DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors
10.1038/s41598-023-32509-4 · doi-reference
