Abstract
Niklas A. Schmacke, Sophia C. Mädler, Georg Wallmann, Andreas Metousis, Varvara Varlamova, Sophia Steigerwald, Sarah B. Christ, Marleen Bérouti, Hartmann Harz, Heinrich Leonhardt, Fabian J. Theis, Veit Hornung
Abstract
Authors
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The genetics of Caenorhabditis elegans
10.1093/genetics/77.1.71 · 1974
Mutations affecting segment number and polarity in Drosophila
10.1038/287795a0 · 1980
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
10.1038/nature15541 · 2015
CRISPR technology: A decade of genome editing is only the beginning
10.1126/science.add8643 · 2023
High-throughput functional genomics using CRISPR–Cas9
10.1038/nrg3899 · 2015
High-content CRISPR screening
10.1038/s43586-021-00093-4 · 2022
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response
10.1016/j.cell.2016.11.048 · 2016
Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq
10.1016/j.cell.2016.11.039 · 2016
Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens
10.1016/j.cell.2016.11.038 · 2016
Pooled CRISPR screening with single-cell transcriptome readout
Institutions
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Provenance
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Confidence 100%
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Confidence 95%
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10.1038/nmeth.4177 · 2017
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq
10.1016/j.cell.2022.05.013 · 2022
Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits
10.1016/j.cell.2025.02.012 · 2025
Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
10.1016/j.cell.2025.09.006 · 2025
High-content CRISPR activation screens identify synthetically lethal RNA-based mechanisms to sensitize cancer cells to targeted T cell cytotoxicity
10.1038/s41588-026-02561-7 · 2026
SPACE: multimodal spatial CRISPR screening with whole-transcriptome readout at subcellular resolution in 3D models
2026
Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens
10.1016/j.cell.2018.09.022 · 2018
Imaging-based screens of pool-synthesized cell libraries
10.1038/s41592-020-01053-8 · 2021
Spatial CRISPR genomics identifies regulators of the tumor microenvironment
10.1016/j.cell.2022.02.015 · 2022
Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks
10.1016/j.cell.2018.11.022 · 2019
Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome
2025
Scaling perturbations: beyond genome-scale CRISPR screens
2026
Genome-wide single-cell perturbation screens with VIPerturb-seq
2026
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks
10.1016/j.cell.2015.06.059 · 2015
Genome-scale CRISPR-Cas9 knockout screening in human cells
10.1126/science.1247005 · 2014
Genetic screens in human cells using the CRISPR-Cas9 system
10.1126/science.1246981 · 2014
Human NLRP1 is a sensor for double-stranded RNA
10.1126/science.abd0811 · 2021
Microscopy-Based High-Content Screening
10.1016/j.cell.2015.11.007 · 2015
Subcellular localization as a driver of protein function
10.1038/s41580-026-00947-3 · 2026
Morphology and gene expression profiling provide complementary information for mapping cell state
10.1016/j.cels.2022.10.001 · 2022
Single-cell and multivariate approaches in genetic perturbation screens
10.1038/nrg3768 · 2015
Genetic and molecular architecture of complex traits
10.1016/j.cell.2024.01.023 · 2024
Optical Pooled Screens in Human Cells
10.1016/j.cell.2019.09.016 · 2019
The phenotypic landscape of essential human genes
10.1016/j.cell.2022.10.017 · 2022
Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
10.1038/s41587-024-02391-0 · 2025
NIS-Seq enables cell-type-agnostic optical perturbation screening
10.1038/s41587-024-02516-5 · 2025
Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap
10.1038/s41587-024-02386-x · 2025
The one-week automated genome-wide optical pooled screen
2026
Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects
10.1016/j.cell.2026.04.031 · 2026
A genome-wide optical pooled screen reveals regulators of cellular antiviral responses
10.1073/pnas.2210623120 · 2023
A genome-wide atlas of human cell morphology
10.1038/s41592-024-02537-7 · 2025
HeLa-CCL2 cell heterogeneity studied by single-cell DNA and RNA sequencing
10.1371/journal.pone.0225466 · doi-reference
Synthesis of an arrayed sgRNA library targeting the human genome
10.1038/srep14987 · doi-reference
Cellpose 2.0: how to train your own model
10.1038/s41592-022-01663-4 · doi-reference
SciPy 1.0: fundamental algorithms for scientific computing in Python
10.1038/s41592-019-0686-2 · doi-reference
Protein Contaminants Matter: Building Universal Protein Contaminant Libraries for DDA and DIA Proteomics
10.1021/acs.jproteome.2c00145 · doi-reference
SCANPY: large-scale single-cell gene expression data analysis
10.1186/s13059-017-1382-0 · doi-reference
DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput
10.1038/s41592-019-0638-x · doi-reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · doi-reference
Stitching and registering highly multiplexed whole-slide images of tissues and tumors using ASHLAR
10.1093/bioinformatics/btac544 · doi-reference
Improved vectors and genome-wide libraries for CRISPR screening
10.1038/nmeth.3047 · doi-reference
The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes
10.1111/j.1600-0854.2008.00701.x · doi-reference
Self-guarding of MORC3 enables virulence factor-triggered immunity
10.1038/s41586-021-04054-5 · doi-reference
ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes
10.1038/s41467-025-65115-1 · doi-reference
CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly
10.1038/s41586-025-10064-4 · doi-reference
CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis
10.1038/s41586-026-10161-y · doi-reference
Homeostatic regulation of STING by retrograde membrane traffic to the ER
10.1038/s41467-020-20234-9 · doi-reference
Human Monocytes Engage an Alternative Inflammasome Pathway
10.1016/j.immuni.2016.01.012 · doi-reference
IKKbeta primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network
10.1016/j.immuni.2022.10.021 · doi-reference
TMEM199 Deficiency Is a Disorder of Golgi Homeostasis Characterized by Elevated Aminotransferases, Alkaline Phosphatase, and Cholesterol and Abnormal Glycosylation
10.1016/j.ajhg.2015.12.011 · doi-reference
Assembly of the yeast vacuolar H+-ATPase occurs in the endoplasmic reticulum and requires a Vma12p/Vma22p assembly complex
10.1083/jcb.142.1.39 · doi-reference
Activation of STING by targeting a pocket in the transmembrane domain
10.1038/s41586-022-04559-7 · doi-reference
The discovery of potent small molecule activators of human STING
10.1016/j.ejmech.2020.112869 · doi-reference
GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus
10.1038/ncb1773 · doi-reference
Predicting cellular responses to perturbation across diverse contexts with State
10.1016/j.cell.2026.07.052 · doi-reference
Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture
10.1038/s42255-026-01459-2 · doi-reference
YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking
10.4049/jimmunol.1900387 · doi-reference
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling
10.1038/s41467-023-36132-9 · doi-reference
Design of amidobenzimidazole STING receptor agonists with systemic activity
10.1038/s41586-018-0705-y · doi-reference
SLC19A1 Is an Importer of the Immunotransmitter cGAMP
10.1016/j.molcel.2019.05.006 · doi-reference
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP
10.1016/j.molcel.2020.10.021 · doi-reference
Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
10.1016/j.immuni.2021.03.011 · doi-reference
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
10.1016/j.cell.2017.09.039 · doi-reference
Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
10.1016/j.cels.2024.11.004 · doi-reference
A conserved ion channel function of STING mediates noncanonical autophagy and cell death
10.1038/s44319-023-00045-x · doi-reference
ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation
10.1016/j.cell.2025.01.027 · doi-reference
Human STING is a proton channel
10.1126/science.adf8974 · doi-reference
Clathrin-associated AP-1 controls termination of STING signalling
10.1038/s41586-022-05354-0 · doi-reference
STING trafficking as a new dimension of immune signaling
10.1084/jem.20220990 · doi-reference
Deficiency in coatomer complex I causes aberrant activation of STING signalling
10.1038/s41467-022-29946-6 · doi-reference
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling
10.1084/jem.20200600 · doi-reference