Abstract
No public abstract is available from the verified source records.
Kinza Rizwan, Sai Prasada Rao Manikonda, Heidi Dowst, Patricia Castro, Maria Elisa Ruiz Echartea, Cristian Coarfa, Michael Ittmann, Neda Zarrin-Khameh, Quillan Huang, Martha Mims, Salma Kaochar
Abstract
Authors
No local reference links have been materialized yet.
No local citing links have been materialized yet.
Cancer statistics, 2025
2025
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
10.1038/ng.2279 · 2012
SPOP mutations in prostate cancer across demographically diverse patient cohorts
10.1593/neo.131704 · 2014
The emerging role of speckle-type POZ protein (SPOP) in cancer development
10.1016/j.drudis.2014.07.009 · 2014
The ubiquitin ligase adaptor SPOP in cancer
10.1111/febs.15056 · 2019
Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer
10.1158/0008-5472.can-14-0476 · 2014
Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
10.1073/pnas.1304502110 · 2013
SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein
10.1038/onc.2017.80 · 2017
SPOP Mutations Target STING1 Signaling in Prostate Cancer and Create Therapeutic Vulnerabilities to PARP Inhibitor-Induced Growth Suppression
10.1158/1078-0432.ccr-23-1439 · 2023
Institutions
No ROR-resolved institution is linked to this work yet.
Provenance
crossref
Confidence 100%
pubmed
Confidence 98%
unpaywall
Confidence 95%
datacite
Confidence 0%
TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer
10.1016/j.ccell.2016.04.012 · 2016
Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer
10.1126/science.1250255 · 2014
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression
10.1016/j.molcel.2015.07.026 · 2015
SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase
10.1016/j.celrep.2015.09.083 · 2015
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
10.1038/nm.4378 · 2017
Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer
10.1016/j.eururo.2020.06.033 · 2020
Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer
10.1016/j.celrep.2021.109665 · 2021
SPOP mutation leads to genomic instability in prostate cancer
10.7554/elife.09207 · 2015
SPOP mutations increase PARP inhibitor sensitivity via CK2/PIAS1/SPOP axis in prostate cancer
10.1172/jci.insight.186871 · 2025
Molecular features and race-associated outcomes of SPOP-mutant metastatic castration-resistant prostate cancer
10.1002/pros.24481 · 2023
Clinical and genomic features of SPOP-mutant prostate cancer
10.1002/pros.24269 · 2022
Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry
10.1371/journal.pgen.1008641 · 2020
Racial Differences in Genomic Profiling of Prostate Cancer
10.1056/nejmc2000069 · 2020
The Molecular Taxonomy of Primary Prostate Cancer
10.1016/j.cell.2015.10.025 · 2015
Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors
10.1158/1078-0432.ccr-21-2577 · 2022
Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
10.1016/j.cell.2018.03.022 · 2018
Scalable open science approach for mutation calling of tumor exomes using multiple genomic pipelines
10.1016/j.cels.2018.03.002 · 2018
The Impact of PIK3R1 Mutations and Insulin-PI3K-Glycolytic Pathway Regulation in Prostate Cancer
10.1158/1078-0432.ccr-21-4272 · 2022
Microsatellite instability, tumor mutational burden, and response to immune checkpoint blockade in patients with prostate cancer
10.1158/1078-0432.ccr-23-3403 · 2024
Race and Genetic Alterations in Prostate Cancer
2021
Genomic correlates of clinical outcome in advanced prostate cancer
10.1073/pnas.1902651116 · 2019
Cancer statistics for African American and Black people, 2025
2025
Prevalence and prognostic significance of TMPRSS2-ERG gene fusion in lymph node positive prostate cancers
10.1002/pros.22882 · 2014
Characterizing the molecular features of ERG-positive tumors in primary and castration resistant prostate cancer
10.1002/pros.23171 · 2016
TMPRSS2:ERG Gene Fusions in Prostate Cancer of West African Men and a Meta-Analysis of Racial Differences
10.1093/aje/kwx235 · 2017
Integrative clinical genomics of advanced prostate cancer
10.1016/j.cell.2015.05.001 · 2015
Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer
10.1056/nejmoa1603144 · 2016
Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization
10.1091/mbc.e11-11-0965 · 2012
Oncogenic KRAS signalling promotes the Wnt/beta-catenin pathway through LRP6 in colorectal cancer
10.1038/onc.2014.416 · 2015
A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway
10.1074/jbc.m109.094334 · 2010
The Role of Wnt Signalling in Angiogenesis
2017
seaborn: statistical data visualization
10.21105/joss.03021 · doi-reference
Matplotlib: A 2D graphics environment
10.1109/mcse.2007.55 · doi-reference
Data Structures for Statistical Computing in Python
10.25080/majora-92bf1922-00a · doi-reference
Complex heatmaps reveal patterns and correlations in multidimensional genomic data
10.1093/bioinformatics/btw313 · doi-reference
Welcome to the Tidyverse
10.21105/joss.01686 · doi-reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · doi-reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · doi-reference
Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
10.1038/nm.4053 · doi-reference
Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics
10.1016/j.eururo.2020.03.024 · doi-reference
Integrative genomic profiling of human prostate cancer
10.1016/j.ccr.2010.05.026 · doi-reference
Clinical validation of the tempus xT next-generation targeted oncology sequencing assay
10.18632/oncotarget.26797 · doi-reference
Identification of SPOP related metabolic pathways in prostate cancer
10.18632/oncotarget.21460 · doi-reference
Comparative analysis of p16 expression among African American and European American prostate cancer patients
10.1002/pros.23833 · doi-reference
On the interpretation of χ2 from contingency tables, and the calculation of P
10.2307/2340521 · doi-reference
The long tail of oncogenic drivers in prostate cancer
10.1038/s41588-018-0078-z · doi-reference
SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling
10.1016/j.ccell.2017.02.004 · doi-reference
The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression
10.1016/j.cell.2018.03.029 · doi-reference
XIRP2, an actin-binding protein essential for inner ear hair-cell stereocilia
10.1016/j.celrep.2015.02.042 · doi-reference
Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease
10.1016/j.gene.2015.06.027 · doi-reference
MYH7 in cardiomyopathy and skeletal muscle myopathy
10.1007/s11010-023-04735-x · doi-reference
On a Test of Whether one of Two Random Variables is Stochastically Larger than the Other
10.1214/aoms/1177730491 · doi-reference
Distinct TERB1 Domains Regulate Different Protein Interactions in Meiotic Telomere Movement
10.1016/j.celrep.2017.10.061 · doi-reference
Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer
10.1158/0008-5472.can-11-2127 · doi-reference
Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/beta-catenin to induce exit from quiescence
10.1016/j.celrep.2023.112561 · doi-reference
A Phase II Study of ERK Inhibition by Ulixertinib (BVD-523) in Metastatic Uveal Melanoma
10.1158/2767-9764.crc-24-0036 · doi-reference
Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation
10.15252/embj.201490041 · doi-reference
Multiomics of Bohring-Opitz syndrome truncating ASXL1 mutations identify canonical and noncanonical Wnt signaling dysregulation
10.1172/jci.insight.167744 · doi-reference
Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT)
10.1016/j.brainres.2006.07.122 · doi-reference