POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells
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Molecular cloning of drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes
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The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
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Template and primer requirements for DNA Pol θ-mediated end joining
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Structural basis of DNA polymerase θ mediated DNA end joining
10.1093/nar/gkac1201 · 2023
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ
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Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts
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Human DNA polymerase θ grasps the primer terminus to mediate DNA repair
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DNA polymerase theta (Polθ) - an error-prone polymerase necessary for genome stability
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Targeting the DNA repair enzyme polymerase θ in cancer therapy
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Beyond PARP-POLθ as an anticancer target
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Synthetic lethality targeting Polθ
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Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
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Genome protection by DNA polymerase θ
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Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors
10.1038/s41467-024-46593-1 · 2024
Identification of RP-6685, an orally bioavailable compound that inhibits the DNA polymerase activity of Polθ
10.1021/acs.jmedchem.2c00998 · 2022
The discovery of RP-2119: a potent, selective, and orally bioavailable Polθ ATPase inhibitor
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Discovery of nonpeptide, environmentally sensitive fluorescent probes for imaging p53-MDM2 interactions in living cell lines and tissue slice
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A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
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Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
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Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models
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