Abstract
Michele Fornaro, Nicolas A. Nunez, Chiara Di Lorenzo, Andrè Ferrer Carvalho, Balwinder Singh, Marin Veldic, Fabio Sambataro, Mark H. Rapaport, Michael Berk, Susan L. McElroy, Mark A. Frye, Alessandro Miola
Abstract
Authors
No local reference links have been materialized yet.
No local citing links have been materialized yet.
Efficacy and safety of palmitoylethanolamide as an adjunctive treatment for acute mania: a randomized, double-blind, placebo-controlled trial
10.1111/pcn.13441 · 2022
The effect of adding curcumin to sodium valproate in treatment of patients with bipolar disorder in the acute phase of mania: a randomized double-blind clinical trial
10.3389/fpsyt.2023.1068277 · 2023
Short-Term effects of folate supplementation in combination with vitamin B6 for treating acute manic episodes in bipolar I Disorder: a randomized controlled trial
10.1002/brb3.70432 · 2025
Mitochondrial complex i activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder
10.1001/archgenpsychiatry.2010.22 · 2010
A systematic review of nutraceuticals for the treatment of bipolar disorder
10.1177/0706743720961734 · 2021
The efficacy of vitamin B6 as an adjunctive therapy to lithium in improving the symptoms of acute mania in patients with bipolar disorder, type 1; a double-blind, randomized, placebo-controlled, clinical trial
10.1002/brb3.2394 · 2021
Netmeta: an R package for network meta-analysis using frequentist methods
10.18637/jss.v106.i02 · 2023
The Bech-Rafaelsen mania scale and the Hamilton depression Scale: evaluation of homogeneity and inter-observer reliability
Institutions
No ROR-resolved institution is linked to this work yet.
Provenance
crossref
Confidence 100%
pubmed
Confidence 98%
unpaywall
Confidence 95%
datacite
Confidence 0%
10.1111/j.1600-0447.1979.tb04484.x · 1979
Unresolved referenced work
1961
Unresolved referenced work
1996
Folic acid efficacy as an alternative drug added to sodium valproate in the treatment of acute phase of mania in bipolar disorder: a double-blind randomized controlled trial
10.1111/j.1600-0447.2009.01368.x · 2009
Omega-3 fatty acids in bipolar patients with a low omega-3 index and reduced heart rate variability: the “BIPO-3” trial
10.1186/s40345-022-00253-9 · 2022
N-Acetyl cysteine for depressive symptoms in bipolar Disorder-A Double-Blind randomized placebo-controlled trial
10.1016/j.biopsych.2008.04.022 · 2008
DSM-IV: diagnostic and statistical manual of mental disorders
10.1001/jama.1994.03520100096046 · 1994
Maintenance N-acetyl cysteine treatment for bipolar disorder: a double-blind randomized placebo controlled trial
10.1186/1741-7015-10-91 · 2012
A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo
10.1186/s12916-019-1280-2 · 2019
Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder
10.1017/neu.2020.25 · 2020
A placebo-controlled trial of acetyl-l-carnitine and α-lipoic acid in the treatment of bipolar depression
10.1097/jcp.0b013e31829a83f5 · 2013
Inositol as an add-on treatment for bipolar depression
10.1034/j.1399-5618.2000.020107.x · 2000
Randomized placebo-controlled adjunctive study of an extract of Withania somnifera for cognitive dysfunction in bipolar disorder
10.4088/jcp.13m08413 · 2013
Conceptual and technical challenges in network meta-analysis
10.7326/0003-4819-159-2-201307160-00008 · 2013
Efficacy of 42 pharmacologic cotreatment strategies added to antipsychotic monotherapy in schizophrenia: systematic overview and quality appraisal of the meta-analytic evidence
10.1001/jamapsychiatry.2017.0624 · 2017
Mechanisms and clinical applications of palmitoylethanolamide (PEA) in the treatment of neuropathic pain
10.1007/s10787-024-01623-8 · 2025
The efficacy of adjunctive Garcinia mangostanaLinn. (mangosteen) pericarp extract for bipolar depression: 24-week randomised controlled trial
10.1192/bjp.2025.108 · 2025
Antiepileptic drugs for the acute and maintenance treatment of bipolar disorder
10.1080/10673220127901 · 2001
The never-ending problem: sample size matters
10.1016/j.euroneuro.2023.10.002 · 2023
Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: a randomized controlled trial
10.1111/bdi.12652 · 2018
Palmitoylethanolamide: a multifunctional molecule for Neuroprotection, chronic Pain, and immune modulation
10.3390/biomedicines13061271 · 2025
The efficacy of adjunctive N-acetylcysteine in acute bipolar depression: a randomized placebo-controlled study
10.1016/j.jad.2018.10.083 · 2019
Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands
10.2174/0929867321666140303143455 · 2014
Nutraceuticals and phytoceuticals in the treatment of schizophrenia: a systematic review and network meta-analysis “Nutra NMA SCZ
10.1038/s41380-024-02645-y · 2025
The concept and management of acute episodes of treatment-resistant bipolar disorder: a systematic review and exploratory meta-analysis of randomized controlled trials
10.1016/j.jad.2020.07.109 · 2020
Nutraceuticals and phytoceuticals for the treatment of major depressive disorder: a systematic review and network meta-analysis
10.1038/s41380-026-03759-1 · 2026
Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study
10.1192/bjp.188.1.46 · 2006
The effect of adjunctive nutraceuticals in bipolar disorder: a systematic review of randomized placebo-controlled trials
10.1016/j.jad.2019.04.039 · 2019
Supplementation of Omega-3 increases serum levels of brain-derived neurotrophic factor and decreases depression status in patients with bipolar Disorder: a Randomized, Double-Blind, placebo-controlled clinical trial
10.1111/jhn.70076 · 2025
A meta-epidemiological study of positive results in clinical nutrition research: the good, the bad and the ugly of statistically significant findings
10.3390/nu14235164 · 2022
A rating scale for depression
10.1136/jnnp.23.1.56 · 1960
Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies
10.1002/jrsm.1044 · 2012
Unresolved referenced work
2022
Adjunctive herbal medicine with carbamazepine for bipolar disorders: a double-blind, randomized, placebo-controlled study
10.1016/j.jpsychires.2005.06.002 · doi-reference
Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: a double-blind, randomized, placebo-controlled, clinical trial
10.1016/j.jad.2023.10.121 · doi-reference
A rating scale for mania: reliability, validity and sensitivity
10.1192/bjp.133.5.429 · doi-reference
Evaluation of inconsistency in networks of interventions
10.1093/ije/dys222 · doi-reference
Nutraceuticals in mood disorders: current knowledge and future directions
10.1097/yco.0000000000000826 · doi-reference
A randomized, double-blind, placebo-controlled, proof-of-concept trial of creatine monohydrate as adjunctive treatment for bipolar depression
10.1007/s00702-017-1817-5 · doi-reference
Industry involvement and transparency in the most cited clinical trials, 2019-2022
10.1001/jamanetworkopen.2023.43425 · doi-reference
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: the world federation of societies of biological psychiatry (WFSBP) and Canadian Network for mood and anxiety treatments (CANMAT) taskforce
10.1080/15622975.2021.2013041 · doi-reference
Ranking treatments in frequentist network meta-analysis works without resampling methods
10.1186/s12874-015-0060-8 · doi-reference
Interpretation of random effects meta-analyses
10.1136/bmj.d549 · doi-reference
Therapeutic approaches employing natural compounds and derivatives for treating bipolar disorder: emphasis on experimental models of the manic phase
10.1007/s11011-021-00776-7 · doi-reference
The basal pharmacology of Palmitoylethanolamide
10.3390/ijms21217942 · doi-reference
Omega-3 fatty acids for the treatment of bipolar disorder Symptoms: a narrative review of the current clinical evidence
10.3390/md23020084 · doi-reference
Understanding the molecular mechanisms underlying mood stabilizer treatments in bipolar disorder: potential involvement of epigenetics
10.1016/j.neulet.2016.06.045 · doi-reference
Epigenetics and bipolar disorder: new opportunities and challenges
10.1002/ajmg.c.20015 · doi-reference
CINeMA: an approach for assessing confidence in the results of a network meta-analysis
10.1371/journal.pmed.1003082 · doi-reference
A new depression scale designed to be sensitive to change
10.1192/bjp.134.4.382 · doi-reference
A novel insight into the antidepressant effect of cannabidiol: possible involvement of the 5-HT1A, CB1, GPR55, and PPAR\uc0\u947 receptors Cannabidiol and brain function: current knowledge and future perspectives
10.1093/ijnp/pyae064 · doi-reference
Evaluating the effect of Coenzyme Q10 augmentation on treatment of bipolar depression: a double-blind controlled clinical trial
10.1097/jcp.0000000000000938 · doi-reference
A 52-week prophylactic randomised control trial of omega-3 polyunsaturated fatty acids in bipolar disorder
10.1111/bdi.13037 · doi-reference
The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management
10.1002/wps.20997 · doi-reference
Vitamin D supplementation in bipolar depression: a double blind placebo controlled trial
10.1016/j.jpsychires.2017.07.021 · doi-reference
Stimulation of peroxisome proliferator-activated Receptor-α by N-palmitoylethanolamine engages Allopregnanolone biosynthesis to modulate emotional behavior
10.1016/j.biopsych.2019.02.006 · doi-reference
Quantifying publication bias in meta-analysis
10.1111/biom.12817 · doi-reference
Advances in molecular psychiatry–March 2023: mitochondrial function, stress, neuroinflammation–bipolar disorder, psychosis, and Alzheimer’s disease
10.1038/s41380-023-01968-6 · doi-reference
Network meta-analyses should be the highest level of evidence in treatment guidelines
10.1007/s00406-016-0715-4 · doi-reference
Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
10.1016/j.biopsych.2006.03.056 · doi-reference
Influence of adjuvant Coenzyme Q10 on inflammatory and oxidative stress biomarkers in patients with bipolar disorders during the depressive episode
10.1007/s11033-019-04989-z · doi-reference
The challenge of reforming nutritional epidemiologic research
10.1001/jama.2018.11025 · doi-reference
The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations
10.7326/m14-2385 · doi-reference
Quantifying heterogeneity in a meta-analysis
10.1002/sim.1186 · doi-reference