Abstract
Fang Guo, Xi‐Biao He
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Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis
10.7554/elife.85751 · 2023
Sonic hedgehog signaling is negatively regulated in reactive astrocytes after forebrain stab injury
10.1038/s41598-018-37555-x · 2019
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
10.1126/science.1206936 · 2011
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
10.1038/nature24016 · 2017
The molecular basis of water transport in the brain
10.1038/nrn1252 · 2003
Aging-related down-regulation of neprilysin, a putative β-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of β-amyloid plaques
10.1016/s0304-3940(03)00030-2 · 2003
Tripartite synapses: glia, the unacknowledged partner
10.1016/s0166-2236(98)01349-6 · 1999
GLUT4 mobilization supports energetic demands of active synapses
10.1016/j.neuron.2016.12.020 · 2017
Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology
10.1007/s00401-021-02275-6 · 2021
Astrocyte calcium signaling: the third wave
10.1038/nn.4201 · 2016
Increasing hexokinase 1 expression improves mitochondrial and glycolytic functional deficits seen in sporadic Alzheimer’s disease astrocytes
10.1038/s41380-024-02746-8 · 2025
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
10.1038/s41591-023-02380-x · 2023
The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer’s and Huntington’s diseases
10.1523/jneurosci.3516-14.2015 · 2015
Astrocytes functionally integrate multiple synapses via specialized leaflet domains
10.1016/j.cell.2025.08.036 · 2025
Aducanumab therapy to treat Alzheimer’s disease: a narrative review
10.1155/2022/9343514 · 2022
CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity
10.1038/89490 · 2001
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
10.1186/s13024-024-00788-8 · 2025
Early involvement of D-serine in β-amyloid-dependent pathophysiology
10.1007/s00018-025-05691-z · 2025
NF-κB and TNF affect the astrocytic differentiation from neural stem cells
10.3390/cells10040840 · 2021
Aβ oligomers induce glutamate release from hippocampal neurons
10.2174/156720511796391917 · 2011
Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load
10.1038/s41380-021-01193-z · 2021
Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG
10.2967/jnumed.110.087031 · 2012
Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease
10.1186/s40478-018-0606-1 · 2018
BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease
10.1186/1750-1326-7-52 · 2012
Apolipoprotein E: structural insights and links to Alzheimer disease pathogenesis
10.1016/j.neuron.2020.10.008 · 2021
Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau
10.1016/j.neuron.2025.04.027 · 2025
Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy
10.1126/science.ads3972 · 2026
High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia
10.1111/jnc.14554 · 2018
Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes
10.1186/ar4162 · 2013
FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
10.1073/pnas.1014154108 · 2011
Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer’s disease
10.1016/j.jphs.2020.05.009 · 2020
Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model
10.1186/s13041-021-00823-5 · 2021
Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function
2025
Motor learning and dopamine-dependent striatal synaptic plasticity are controlled by astrocytic MEGF10
10.1038/s41467-026-69129-1 · 2026
Molecular mechanism of ligand gating and opening of NMDA receptor
10.1038/s41586-024-07742-0 · 2024
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production
10.1038/s41593-020-00735-y · 2020
Astrocyte regulation of synapse formation, maturation, and elimination
10.1101/cshperspect.a041352 · 2024
Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment
10.1186/s13195-021-00804-9 · 2021
Siponimod (BAF312) activates Nrf2 while hampering NFκB in human astrocytes, and protects from astrocyte-induced neurodegeneration
10.3389/fimmu.2020.00635 · 2020
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation
10.1126/sciadv.aaq1702 · 2018
Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism
10.1186/s12974-023-02722-z · doi-reference
Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity
10.1186/s40035-025-00474-9 · doi-reference
Astrocytic induction of triglyceride lipolysis in AD-associated pathology and neuroinflammation
10.1002/alz.093056 · doi-reference
BACE1 regulates expression of clusterin in astrocytes for enhancing clearance of β-amyloid peptides
10.1186/s13024-023-00611-w · doi-reference
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
10.1038/s41591-019-0695-9 · doi-reference
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
10.1038/s41467-020-19264-0 · doi-reference
The contribution of activated astrocytes to Aβ production: implications for Alzheimer’s disease pathogenesis
10.1186/1742-2094-8-150 · doi-reference
Aβ oligomers promote lipid droplet accumulation and inflammatory responses in astrocytes but not neurons
10.1016/j.brainresbull.2025.111556 · doi-reference
Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence
10.1038/s41593-021-00949-8 · doi-reference
Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains
10.1001/jamaneurol.2016.4370 · doi-reference
APOE effects on regional tau in preclinical Alzheimer’s disease
10.1186/s13024-022-00590-4 · doi-reference
Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition
10.1113/jphysiol.2014.278754 · doi-reference
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
10.1186/s13024-025-00796-2 · doi-reference
C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation
10.1186/s12974-021-02167-2 · doi-reference
IKK2/NF-κB activation in astrocytes reduces amyloid β deposition: a process associated with specific microglia polarization
10.3390/cells10102669 · doi-reference
Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma
10.1186/s12974-020-01930-1 · doi-reference
AQP4 association with amyloid deposition and astrocyte pathology in the Tg-ArcSwe mouse model of Alzheimer’s disease
10.3233/jad-160957 · doi-reference
The current agonists and positive allosteric modulators of α 7 nAChR for CNS indications in clinical trials
10.1016/j.apsb.2017.09.001 · doi-reference
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
10.1038/s41582-019-0228-7 · doi-reference
Vimentin immunoreactivity in normal and pathological human brain tissue
10.1007/bf00311389 · doi-reference
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits
10.1186/s13024-015-0056-1 · doi-reference
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases
10.1126/scitranslmed.abe5640 · doi-reference
Disruption of BAG3-mediated BACE1 stabilization alleviates neuropathology and memory deficits in a mouse model of Alzheimer’s disease
10.1126/sciadv.adt7981 · doi-reference
Up-regulation of neprilysin mediates the protection of fructo-oligosaccharides against Alzheimer’s disease
10.1039/d0fo00161a · doi-reference
Complement C3 is activated in human AD brain and is required for neurodegeneration in mouse models of amyloidosis and tauopathy
10.1016/j.celrep.2019.07.060 · doi-reference
Multiscale proteomic modeling reveals protein networks driving Alzheimer’s disease pathogenesis
10.1016/j.cell.2025.08.038 · doi-reference
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia
10.1016/j.neuron.2021.03.024 · doi-reference
Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer’s brain: Aβ-degrading enzymes profiling in Alzheimer’s brain
10.1111/j.1471-4159.2010.06899.x · doi-reference
β-Amyloid1–42 binds to α7 nicotinic acetylcholine receptor with high affinity
10.1074/jbc.275.8.5626 · doi-reference
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
10.1038/s41467-020-20322-w · doi-reference
The accumulation of tau-immunoreactive hippocampal granules and corpora amylacea implicates reactive glia in tau pathogenesis during aging
10.1016/j.isci.2020.101255 · doi-reference
Calcium-dependent signaling in astrocytes: downstream mechanisms and implications for cognition
10.1111/jnc.70019 · doi-reference
The role of sphingosine 1-phosphate metabolism in brain health and disease
10.1016/j.pharmthera.2023.108381 · doi-reference
Astrocytes and microglia: in sickness and in health
10.1016/j.tins.2020.01.003 · doi-reference
Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection
10.1111/jnc.14064 · doi-reference
Evaluation of 11C-BU99008, a positron emission tomography ligand for the Imidazoline2 binding site in human brain
10.2967/jnumed.118.208009 · doi-reference
Fibroblast growth factor signalling: from development to cancer
10.1038/nrc2780 · doi-reference
Bridging regional neurovascular unit heterogeneity and cognitive function: a review
10.1186/s12987-025-00697-y · doi-reference
Astrocytic GLUT1 deletion in adult mice enhances glucose metabolism and resilience to stroke
10.1038/s41467-025-59400-2 · doi-reference
Adenosine signalling to astrocytes coordinates brain metabolism and function
10.1038/s41586-024-07611-w · doi-reference