N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain
10.1074/jbc.m112.395830 · doi-reference
Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism
10.1211/jpp.61.01.0007 · doi-reference
A novel prophylactic effect of furosemide treatment on autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)
10.1016/j.eplepsyres.2013.08.018 · doi-reference
Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation
10.1074/jbc.m109.043620 · doi-reference
BDNF-TrkB signaling pathway mediates the induction of epileptiform activity induced by a convulsant drug cyclothiazide
10.1016/j.neuropharm.2009.04.007 · doi-reference
M-calpain activation facilitates seizure induced KCC2 down regulation
10.3389/fnmol.2018.00287 · doi-reference
Coordinated downregulation of KCC2 and GABAA receptor contributes to inhibitory dysfunction during seizure induction
10.1016/j.bbrc.2020.08.082 · doi-reference
Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation
10.1523/jneurosci.3104-06.2007 · doi-reference
Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus
10.1111/j.1460-9568.2008.06234.x · doi-reference
Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo
10.1523/jneurosci.5205-14.2015 · doi-reference
KCC2 activity is critical in limiting the onset and severity of status epilepticus
10.1073/pnas.1415126112 · doi-reference
Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2
10.1523/jneurosci.5265-03.2004 · doi-reference
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
10.1038/16697 · doi-reference
BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion
10.1083/jcb.200209011 · doi-reference
Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats
10.1016/s0006-8993(00)02121-1 · doi-reference
Modification of seizure activity by electrical stimulation. 3. Mechanisms
10.1016/0013-4694(72)90178-2 · doi-reference
Cyclothiazide induces robust epileptiform activity in rat hippocampal neurons both in vitro and in vivo
10.1113/jphysiol.2005.103812 · doi-reference
Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain
10.1523/jneurosci.6265-11.2012 · doi-reference
Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+](0) regulation
10.1152/ajpcell.1997.273.5.c1516 · doi-reference
Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy
10.1523/jneurosci.4390-07.2007 · doi-reference
Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory
10.1073/pnas.0602979103 · doi-reference
Clinical pharmacology of the loop diuretics furosemide and bumetanide in neonates and infants
10.2165/11596620-000000000-00000 · doi-reference
Depolarizing shift in the GABA-induced current reversal potential by lidocaine hydrochloride
10.1016/j.brainres.2010.05.052 · doi-reference
Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures
10.1073/pnas.1810134115 · doi-reference
