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Yiqing Rao, Xiangdong Chen
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From genes and mechanisms to molecular-targeted therapies: the long climb to the cure of cerebral cavernous malformation (CCM) disease
10.1007/978-1-0716-0640-7_1 · 2020
Endothelial adherens junctions at a glance
2013
Cerebral cavernous malformations
2026
10.1227/neu.0000000000003459
10.1227/neu.0000000000003459 · 2026
Contribution of endothelial-to-mesenchymal transition to the pathogenesis of human cerebral and orbital cavernous malformations
10.1093/neuros/nyx078 · 2017
Role of Delta-Notch signaling in cerebral cavernous malformations
10.1007/s10143-015-0699-y · 2016
EndMT contributes to the onset and progression of cerebral cavernous malformations
10.1038/nature12207 · 2013
Cerebral cavernous malformation: immune and inflammatory perspectives
10.3389/fimmu.2022.922281 · 2022
Defective autophagy is a key feature of cerebral cavernous malformations
10.15252/emmm.201505316 · 2015
Fluorescence analysis of reactive oxygen species (ROS) in cellular models of cerebral cavernous malformation disease
10.1007/978-1-0716-0640-7_34 · 2020
Non-coding RNAs in disease: from mechanisms to therapeutics
10.1038/s41576-023-00662-1 · 2024
Cavernous angiomas: deconstructing a neurosurgical disease
10.3171/2019.3.jns181724 · 2019
Somatic PIK3CA mutations in sporadic cerebral cavernous malformations
10.1056/nejmoa2100440 · 2021
Simplex cerebral cavernous malformations with MAP3K3 mutation have distinct clinical characteristics
10.3389/fneur.2022.946324 · 2022
Cerebral cavernous malformations - an overview on genetics, clinical aspects and therapeutic strategies
10.1016/j.jns.2024.123044 · 2024
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
10.1084/jem.20091258 · 2010
Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling
10.1073/pnas.1000132107 · 2010
Crystallographic studies of the cerebral cavernous malformations proteins
10.1007/978-1-0716-0640-7_21 · 2020
CCM3 and cerebral cavernous malformation disease
10.1136/svn-2018-000195 · 2019
Neuroinflammation plays a critical role in cerebral cavernous malformation disease
10.1161/circresaha.122.321129 · 2022
Tooth loss and dementia amongst older adults residing in long-term care facilities in Vancouver: a case-control study
10.1111/ger.12677 · 2023
Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex
10.1038/ncomms8937 · 2015
Review of treatment and therapeutic targets in brain arteriovenous malformation
10.1177/0271678x211026771 · 2021
Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling
10.1038/nature17178 · 2016
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
10.15252/emmm.201505433 · 2016
Regulation of beta1 integrin-Klf2-mediated angiogenesis by CCM proteins
10.1016/j.devcel.2014.12.016 · 2015
DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation
10.1186/s13073-025-01452-6 · 2025
Beyond multiple mechanisms and a unique drug: defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies
2016
Crippling of Kruppel (-like factor 2) by bad flow portends a miRky day for endothelial function
10.1161/circulationaha.111.043299 · 2011
PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations
10.1007/s10143-014-0597-8 · 2015
AKT-ing via microRNA
10.4161/cc.9.16.12634 · 2010
Cellular processes underlying cerebral cavernous malformations: autophagy as another point of view
10.1080/15548627.2015.1125073 · 2016
mTORC1 signaling in brain endothelial progenitors contributes to CCM pathogenesis
10.1161/circresaha.123.324015 · 2024
Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations
10.1093/brain/awad104 · 2023
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism
10.1038/s41586-021-03562-8 · 2021
TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice
10.1186/s12974-020-01853-x · 2020
ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension
10.1016/j.vph.2015.03.017 · 2015
ROCK2 regulates microglia proliferation and neuronal survival after traumatic brain injury
10.1016/j.bbi.2024.01.004 · 2024
miR-101a-3p/ROCK2 axis regulates neuronal injury in Parkinson's disease models
10.18632/aging.205836 · 2024
The roles of ROCK2/CBS-H(2)S pathway in the cerebral ischemia/reperfusion injury
10.1016/j.ijbiomac.2025.144399 · 2025
Natural history of cerebral cavernous malformations
10.1016/b978-0-444-63640-9.00021-7 · doi-reference
Overview of cerebral cavernous malformations: comparison of treatment approaches
10.1136/jnnp-2021-328658 · doi-reference
Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma
10.1038/s43856-023-00265-1 · doi-reference
Single-cell sequencing insights into the transcriptional landscape of cerebral cavernous malformations
10.1007/s10456-025-10011-x · doi-reference
Could propranolol be beneficial in adult cerebral cavernous malformations?
10.1007/s10143-018-01074-0 · doi-reference
Bleeding risk of cerebral cavernous malformations in patients on statin and antiplatelet medication: a cohort study
10.1227/neu.0000000000002480 · doi-reference
Long-term outcomes of gamma knife radiosurgery for cerebral cavernous malformations: 10 years and beyond
10.3346/jkms.2024.39.e229 · doi-reference
Stereotactic radiosurgery (SRS) for patients with brainstem cerebral cavernous malformations (CCMs): an international, multicentric study
10.1038/s41598-024-77140-z · doi-reference
Surgery for cerebral cavernous malformations: a systematic review and meta-analysis
10.1007/s10143-021-01591-5 · doi-reference
CircRNA_0003307 promoted brain microvascular endothelial cell angiogenesis, invasion, and migration in cerebral ischemia-reperfusion injury: potential involvement of miRNA-191-5p/CDK6 pathway
10.1016/j.neuroscience.2024.09.025 · doi-reference
CircRNA and miRNA expression profiles during remote ischemic postconditioning attenuate brain ischemia/reperfusion injury
10.1016/j.brainresbull.2022.04.006 · doi-reference
Lipid nanoparticle-mediated delivery of microRNA-124 reduces neuroinflammation
10.1016/j.biomaterials.2025.123589 · doi-reference
A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases
10.15252/emmm.201506078 · doi-reference
Present insights into the progress in gene therapy delivery systems for central nervous system diseases
10.1016/j.ijpharm.2024.125069 · doi-reference
MiRNA-190 exerts neuroprotective effects against ischemic stroke through Rho/Rho-kinase pathway
10.1007/s00424-020-02490-2 · doi-reference
Vis-a-vis: a focus on genetic features of cerebral cavernous malformations and brain arteriovenous malformations pathogenesis
10.1007/s10072-018-3674-x · doi-reference
Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance
10.1038/s41467-021-26420-7 · doi-reference
Circulating lncRNAs remark expression profile of cerebrovascular malformation endothelial cells
10.1096/fj.202504229r · doi-reference
Polymorphisms in genes related to oxidative stress and inflammation: emerging links with the pathogenesis and severity of Cerebral Cavernous Malformation disease
10.1016/j.freeradbiomed.2021.06.021 · doi-reference
Dysregulated hemostasis and immunothrombosis in cerebral cavernous malformations
10.3390/ijms232012575 · doi-reference
Transcriptome-wide profiling of cerebral cavernous malformations patients reveal important long noncoding RNA molecular signatures
10.1038/s41598-019-54845-0 · doi-reference
Altered expression of long noncoding RNAs in blood after ischemic stroke and proximity to putative stroke risk loci
10.1161/strokeaha.116.013869 · doi-reference
Toward understanding non-coding RNA roles in intracranial aneurysms and subarachnoid hemorrhage
10.1515/tnsci-2017-0010 · doi-reference
Revealing protein-lncRNA interaction
10.1093/bib/bbv031 · doi-reference
Integrated lncRNA function upon genomic and epigenomic regulation
10.1016/j.molcel.2022.05.027 · doi-reference
Genome-wide sequencing reveals small nucleolar RNAs downregulated in cerebral cavernous malformations
10.1007/s10571-018-0602-9 · doi-reference
Decoding the molecular script of 2'-O-ribomethylation: implications across CNS disorders
10.1016/j.heliyon.2024.e39036 · doi-reference
U8 variants on the brain: a small nucleolar RNA and human disease
10.1080/15476286.2022.2048563 · doi-reference
Genetic associations and regulation of expression indicate an independent role for 14q32 snoRNAs in human cardiovascular disease
10.1093/cvr/cvy309 · doi-reference
SnoRNA and lncSNHG: advances of nucleolar small RNA host gene transcripts in anti-tumor immunity
10.3389/fimmu.2023.1143980 · doi-reference
circ_2858 helps blood-brain barrier disruption by increasing VEGFA via sponging miR-93-5p during Escherichia coli meningitis
10.1016/j.omtn.2020.09.034 · doi-reference
HIF-1alpha and VEGF immunophenotypes as potential biomarkers in the prognosis and evaluation of treatment efficacy of atherosclerosis: a systematic review of the literature
10.31083/fbl27004 · doi-reference
miR-21 coordinates tumor growth and modulates KRIT1 levels
10.1016/j.bbrc.2013.07.031 · doi-reference
Prevalence, genetic and clinical characteristics in first-degree relatives of patients with familial cerebral cavernous malformations in China
10.1136/svn-2023-003004 · doi-reference
Lifetime risk of first symptomatic ICH or seizure in familial cerebral cavernous malformations: a multicenter patient data analysis
10.1212/wnl.0000000000213798 · doi-reference
Circulating plasma miRNA homologs in mice and humans reflect familial cerebral cavernous malformation disease
10.1007/s12975-022-01050-3 · doi-reference
miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2
10.1515/med-2021-0222 · doi-reference
MiR-128-3p - a gray eminence of the human central nervous system
10.1016/j.omtn.2024.102141 · doi-reference
Impairment of tight junctions and glucose transport in endothelial cells of human cerebral cavernous malformations
10.1097/nen.0b013e31821bc40e · doi-reference
Blocking signalopathic events to treat cerebral cavernous malformations
10.1016/j.molmed.2020.03.003 · doi-reference