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Evelyna Derhovanessian
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Do autochthonous tumors interfere with effector T cell responses?
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Role of cytomegalovirus in the T cell changes seen in elderly individuals
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Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals
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The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age
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Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration
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Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation
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CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impact of immunosenescence
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Aging and human CD4(+) regulatory T cells
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Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice
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Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+ and CD8+ T cells
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Conditions that diminish myeloid-derived suppressor cell activities stimulate cross-protective immunity
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Immunosenescence and cancer vaccines
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Cytomegalovirus seroprevalence is not higher in patients with mycosis fungoides/Sezary syndrome
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Cytomegalovirus seropositivity is significantly associated with mycosis fungoides and Sezary syndrome
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Are regulatory T-cells linked with aging?
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High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma
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Increased programmed death-1+ tumor-infiltrating lymphocytes in classical Hodgkin lymphoma substantiate reduced overall survival
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Tumor-specific regulatory T cells in cancer patients
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Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer
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Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells
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Increase in tumour-infiltrating lymphocytes with regulatory T cell immunophenotypes and reduced zeta-chain expression in nasopharyngeal carcinoma patients
10.1111/j.1365-2249.2008.03793.x · doi-reference
under revision. Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas
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High frequencies of functionally impaired cytokeratin 18-specific CD8+ T cells in healthy HLA-A2+ donors
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SELDI-TOF-MS ProteinChip array profiling of T-cell clones propagated in long-term culture identifies human profilin-1 as a potential bio-marker of immunosenescence
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Gene expression changes in long-term culture of T-cell clones: genomic effects of chronic antigenic stress in aging and immunosenescence
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Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly
10.4049/jimmunol.176.4.2645 · doi-reference
The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection
10.1182/blood.v97.3.700 · doi-reference
Clonal expansions in acute EBV infection are detectable in the CD8 and not the CD4 subset and persist with a variable CD45 phenotype
10.4049/jimmunol.165.10.5729 · doi-reference
Human T-cell clones in long-term culture as a model of immunosenescence
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