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10.1016/j.phytochem.2024.114099 · doi-reference
Digoxin suppresses pyruvate kinase M2-promoted HIF-1α transactivation in steatohepatitis
10.1016/j.cmet.2018.01.007 · doi-reference
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10.3748/wjg.v29.i12.1824 · doi-reference
Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect
10.1038/s41401-020-00516-0 · doi-reference
The current landscape of the antimicrobial peptide melittin and its therapeutic potential
10.3389/fimmu.2024.1326033 · doi-reference
Sulforaphane diminishes moonlighting of pyruvate kinase M2 and interleukin 1β expression in M1 (LPS) macrophages
10.3389/fimmu.2022.935692 · doi-reference
Bioactive sulforaphane from cruciferous vegetables: Advances in biosynthesis, metabolism, bioavailability, delivery, health benefits, and applications
10.1080/10408398.2024.2354937 · doi-reference
Si-Wu-Tang attenuates hepatocyte PANoptosis and M1 polarization of macrophages in non-alcoholic fatty liver disease by influencing the intercellular transfer of mtDNA
10.1016/j.jep.2024.118057 · doi-reference
Network and experimental pharmacology on mechanism of Si-Wu-tang improving ovarian function in a mouse model of premature ovarian failure induced by cyclophosphamide
10.1016/j.jep.2022.115842 · doi-reference
Network pharmacology based research into the effect and mechanism of Xijiao Dihuang decoction against sepsis
10.1016/j.biopha.2019.109777 · doi-reference
Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review
10.1016/j.jep.2016.03.046 · doi-reference
Flavonoids regulate tumor-associated macrophages – From structure-activity relationship to clinical potential (Review)
10.1016/j.phrs.2022.106419 · doi-reference
Natural sources, biological effects, and pharmacological properties of cynaroside
10.1016/j.biopha.2023.114337 · doi-reference
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis
10.1016/j.chembiol.2022.06.011 · doi-reference
Capsaicin from chili peppers and its analogues and their valued applications: An updated literature review
10.1016/j.foodres.2025.116034 · doi-reference
The role of celastrol in inflammation and diseases
10.1007/s00011-024-01983-5 · doi-reference
Deoxyelephantopin and its isomer isodeoxyelephantopin: Anti-cancer natural products with multiple modes of action
10.3390/molecules27072086 · doi-reference
Shikonin alleviates choroidal neovascularization by inhibiting proangiogenic factor production from infiltrating macrophages
10.1016/j.exer.2021.108823 · doi-reference
Inflammatory choroidal neovascularization: an evidence-based update
10.1016/j.survophthal.2024.12.004 · doi-reference
Shikonin inhibits immune checkpoint PD-L1 expression on macrophage in sepsis by modulating PKM2
10.1016/j.intimp.2023.110401 · doi-reference
Pharmacological properties and derivatives of shikonin-a review in recent years
10.1016/j.phrs.2019.104463 · doi-reference
Novel targets for treating neurodegenerative diseases: The PKM2-STAT3-hnRNPA1 feedback loop
10.1016/j.phrs.2025.107840 · doi-reference
Evolving cognition of the JAK-STAT signaling pathway: Autoimmune disorders and cancer
10.1038/s41392-023-01468-7 · doi-reference
The Warburg effect then and now: from cancer to inflammatory diseases
10.1002/bies.201300084 · doi-reference
Microglia PKM2 mediates neuroinflammation and neuron loss in mice epilepsy through the astrocyte C3-neuron C3R signaling pathway
10.3390/brainsci13020262 · doi-reference
Alpha-synuclein induces microglial migration via PKM2-dependent glycolysis
10.1016/j.ijbiomac.2019.02.029 · doi-reference
Understanding the molecular pathway of triclosan-induced ADHD-like behaviour: Involvement of the hnRNPA1-PKM2-STAT3 feedback loop
10.1016/j.envint.2024.108966 · doi-reference
Neurotoxic effects of triclosan in adolescent mice: Pyruvate kinase M2 dimer regulated Signal transducer and activator of transcription 3 phosphorylation mediated microglia activation and neuroinflammation
10.1016/j.scitotenv.2024.173739 · doi-reference
Amyloid β-based therapy for Alzheimer’s disease: Challenges, successes and future
10.1038/s41392-023-01484-7 · doi-reference
Sirt5-mediated polarization and metabolic reprogramming of macrophage sustain brain function following ischemic stroke
10.1016/j.brainres.2025.149613 · doi-reference
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia
10.1016/j.molimm.2021.10.017 · doi-reference
LncRNA-AC020978 promotes metabolic reprogramming in M1 microglial cells in postoperative cognitive disorder via PKM2
10.1007/s12035-023-03729-6 · doi-reference
Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway
10.1186/s12974-021-02279-9 · doi-reference
Suppressing nuclear translocation of microglial PKM2 confers neuroprotection via downregulation of neuroinflammation after mouse cerebral ischemia-reperfusion injury
10.1016/j.intimp.2024.112880 · doi-reference
PKM2 nuclear translocation promotes glial cell activation and aggravates the brain injury of intracerebral hemorrhage
10.31083/j.jin2206168 · doi-reference
Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury via inhibiting HIF-1α/PKM2/STAT3 signaling
10.1016/j.biopha.2022.113479 · doi-reference
Imbalance in glucose metabolism regulates the transition of microglia from homeostasis to disease-associated microglia stage 1
10.1523/jneurosci.1563-23.2024 · doi-reference
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease
10.1016/j.cmet.2022.02.013 · doi-reference
SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury
10.1177/17534259231166212 · doi-reference
Norisoboldine attenuates sepsis-induced acute lung injury by modulating macrophage polarization via PKM2/HIF-1α/PGC-1α pathway
10.1248/bpb.b21-00457 · doi-reference
