Abstract
Regina Dahlhaus, Israfil Yalcin, Julia Tischer, Ralf J. Braun
Abstract
Authors
Institutions
No ROR-resolved institution is linked to this work yet.
Provenance
crossref
Confidence 100%
pubmed
Confidence 98%
unpaywall
Confidence 95%
datacite
Confidence 0%
No local reference links have been materialized yet.
No local citing links have been materialized yet.
Defective cholesterol metabolism in amyotrophic lateral sclerosis
10.1194/jlr.p071639 · 2017
Amyloid-like interactions within nucleoporin FG hydrogels
10.1073/pnas.0910163107 · 2010
Plasma lipids as biomarkers for Alzheimer’s disease: a systematic review
2020
Modeling the effects of lipid peroxidation during ferroptosis on membrane properties
10.1038/s41598-018-23408-0 · 2018
Mechanics of nuclear membranes
10.1242/jcs.229245 · 2019
Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine
10.1186/s40035-022-00322-0 · 2022
Mitochondrial membrane potential and compartmentalized signaling: Calcium, ROS, and beyond
10.1016/j.redox.2025.103859 · 2025
Sigmar1’s molecular, cellular, and biological functions in regulating cellular pathophysiology
10.3389/fphys.2021.705575 · 2021
Pathological sequelae associated with skeletal muscle atrophy and histopathology in G93A*SOD1 mice
10.3390/muscles2010006 · 2023
Tilt: major factor in sterols’ ordering capability in membranes
10.1021/jp064931u · 2006
Impaired nucleoporins are present in sporadic amyotrophic lateral sclerosis motor neurons that exhibit mislocalization of the 43-kDa TAR DNA-binding protein
10.3988/jcn.2019.15.1.62 · 2019
Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
10.1186/s13046-020-01824-3 · 2021
Cyclodextrin derivatives in pharmaceutics
10.1615/critrevtherdrugcarriersyst.v12.i4.20 · 1995
The role of intranuclear lipids
10.1016/j.biolcel.2004.05.004 · 2004
Nuclear lipid microdomains regulate cell function
10.4161/cib.2.1.7376 · 2009
Involvement of lipids in the pathogenesis of amyotrophic lateral sclerosis
2023
Neuromuscular junction denervation and terminal Schwann cell loss in the hTDP-43 overexpression mouse model of amyotrophic lateral sclerosis
2023
Oxidative stress-mediated lipid peroxidation-derived lipid aldehydes in the pathophysiology of neurodegenerative diseases
10.2174/011570159x342720241014164650 · 2025
The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization
10.1186/s12915-021-00983-9 · 2021
Heterogeneous distribution of filipin-sterol complexes in nuclear membranes
10.1016/0005-2736(81)90411-9 · 1981
A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis
10.1002/ana.22534 · 2011
A common functional allele of the Nogo receptor gene, reticulon 4 receptor (RTN4R), is associated with sporadic amyotrophic lateral sclerosis in a French population
10.3109/21678421.2015.1051988 · 2015
Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord
10.1016/j.neurobiolaging.2008.07.005 · 2010
Grease in the nucleus: insights into the dynamic life of nuclear membranes
10.1007/s00232-022-00272-8 · 2023
Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology
10.7554/elife.67587 · 2021
Inactivation of liver X receptor β leads to adult-onset motor neuron degeneration in male mice
10.1073/pnas.0500634102 · 2005
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
10.1038/s41593-020-0650-6 · 2020
Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment
10.1111/nan.12681 · 2021
Membrane cholesterol depletion in cortical neurons highlights altered NMDA receptor functionality in a mouse model of amyotrophic lateral sclerosis
10.1016/j.bbadis.2017.11.008 · 2018
TDP43 proteinopathy is associated with aberrant DNA methylation in human amyotrophic lateral sclerosis
10.1111/nan.12625 · 2021
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
10.1016/j.bbrc.2006.10.093 · 2006
Iron homeostasis is altered in response to hypoxia and hypothermic preconditioning in brain glial cells
10.3906/sag-2003-41 · 2020
Early and persistent abnormal decoding by glial cells at the neuromuscular junction in an ALS model
10.1523/jneurosci.1379-14.2015 · 2015
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
10.1073/pnas.1222809110 · 2013
Heavy metal neurotoxicants induce ALS-linked TDP-43 pathology
10.1093/toxsci/kfy267 · 2019
Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)
10.1074/jbc.m115.679043 · 2015
Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection
10.1101/gad.194829.112 · 2012
Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS
10.1007/s00401-011-0850-y · 2011
TDP-43 regulates its mRNA levels through a negative feedback loop
10.1038/emboj.2010.310 · 2011
Liver X receptor agonist GW3965 regulates synaptic function upon amyloid beta exposure in hippocampal neurons
10.1007/s12640-017-9845-3 · 2018
Systematic and state-of the science review of the role of environmental factors in amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s Disease
10.1016/j.scitotenv.2021.152504 · doi-reference
Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations
10.1007/s00401-012-1020-6 · doi-reference
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
10.1007/s00401-008-0477-9 · doi-reference
TDP-43 enhances translation of specific mRNAs linked to neurodegenerative disease
10.1093/nar/gky972 · doi-reference
Compartment-dependent mitochondrial alterations in experimental ALS, the effects of mitophagy and mitochondriogenesis
10.3389/fncel.2015.00434 · doi-reference
Targeted next-generation sequencing reveals novel and rare variants in Indian patients with amyotrophic lateral sclerosis
10.1016/j.neurobiolaging.2018.05.012 · doi-reference
Ultrastructural mitochondrial abnormalities in patients with sporadic amyotrophic lateral sclerosis
10.1001/archneur.68.12.1612 · doi-reference
Impaired cytoplasmic–nuclear transport of hypoxia-inducible factor-1α in amyotrophic lateral sclerosis
10.1111/bpa.12040 · doi-reference
TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons
10.1007/s00401-020-02205-y · doi-reference
Cortical frontoparietal network dysfunction in CHMP2B-frontotemporal dementia
10.3389/fnagi.2021.714220 · doi-reference
Shared molecular mechanisms in Alzheimer’s disease and amyotrophic lateral sclerosis: neurofilament-dependent transport of sAPP, FUS, TDP-43 and SOD1, with endoplasmic reticulum-like tubules
10.1159/000439256 · doi-reference
Regulation of brain cholesterol: what role do liver X receptors play in neurodegenerative diseases?
10.3390/ijms20163858 · doi-reference
The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control
10.1093/hmg/ddt594 · doi-reference
Time course of neuropathology in the spinal cord of G86R superoxide dismutase transgenic mice
10.1002/(sici)1096-9861(19980202)391:1<64::aid-cne6>3.0.co;2-p · doi-reference
Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery
10.1016/j.stem.2023.04.017 · doi-reference
Visualizing nuclear pore complex plasticity with pan-expansion microscopy
10.1083/jcb.202409120 · doi-reference
TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons
10.1016/j.bbagrm.2019.194434 · doi-reference
Deregulation of the hypoxia inducible factor-1α pathway in monocytes from sporadic amyotrophic lateral sclerosis patients
10.1016/j.neuroscience.2010.10.040 · doi-reference
A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis
10.3109/17482960802635397 · doi-reference
TDP-43 and tau oligomers in Alzheimer’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia
10.1016/j.nbd.2020.105130 · doi-reference
Regulation of lipid metabolism by the unfolded protein response
10.1111/jcmm.16255 · doi-reference
Electrostatic repulsion governs TDP-43 C-terminal domain aggregation
10.1371/journal.pbio.1002447 · doi-reference
Genetic variability in CHMP2B and frontotemporal dementia
10.1159/000094771 · doi-reference
Cellular stresses induce the nuclear accumulation of importin α and cause a conventional nuclear import block
10.1083/jcb.200312008 · doi-reference
Low density of sigma1 receptors in early Alzheimer’s disease
10.1007/s12149-007-0094-z · doi-reference
Facilitated aggregation of FG nucleoporins under molecular crowding conditions
10.1038/embor.2012.204 · doi-reference
Edaravone mitigates TDP-43 mislocalization in human amyotrophic lateral sclerosis neurons with potential implication of the SIRT1-XBP1 pathway
10.1016/j.freeradbiomed.2025.01.012 · doi-reference
Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington’s disease
10.1016/j.nbd.2014.11.005 · doi-reference
Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases
10.1111/neup.12080 · doi-reference
Levels of membrane fluidity in the spinal cord and the brain in an animal model of amyotrophic lateral sclerosis
10.1007/s10863-011-9348-5 · doi-reference
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
10.1186/1750-1326-6-57 · doi-reference
Nuclear pore basket proteins are tethered to the nuclear envelope and can regulate membrane curvature
10.1016/j.devcel.2015.02.017 · doi-reference
Mitochondrial membrane synthesis, remodelling and cellular trafficking
10.1002/jimd.12766 · doi-reference
Lipid and lipid raft alteration in aging and neurodegenerative diseases: a window for the development of new biomarkers
10.3390/ijms20153810 · doi-reference
TDP-43 pathology in Alzheimer’s disease
10.1186/s13024-021-00503-x · doi-reference
Progressive mitochondrial SOD1G93A accumulation causes severe structural, metabolic and functional aberrations through OPA1 down-regulation in a mouse model of amyotrophic lateral sclerosis
10.3390/ijms22158194 · doi-reference
Epigenetic drift is a determinant of mammalian lifespan
10.1089/rej.2017.2024 · doi-reference
Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum
10.1073/pnas.1424951112 · doi-reference
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease
10.1038/s41467-020-19227-5 · doi-reference
Microglia regulate central nervous system myelin growth and integrity
10.1038/s41586-022-05534-y · doi-reference