Abstract
Shigeki Miyamoto
Abstract
Authors
Institutions
No ROR-resolved institution is linked to this work yet.
Provenance
crossref
Confidence 100%
unpaywall
Confidence 95%
datacite
Confidence 0%
No local reference links have been materialized yet.
No local citing links have been materialized yet.
A novel ras-related gene family
10.1016/0092-8674(85)90058-3 · 1985
Rho GTPases in cell biology
10.1038/nature01148 · 2002
Rho signaling research: history, current status and future directions
10.1002/1873-3468.13087 · 2018
Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells
10.1146/annurev.biochem.68.1.459 · 1999
The RHO family GTPases: mechanisms of regulation and signaling
10.3390/cells10071831 · 2021
A current overview of RhoA, RhoB, and RhoC functions in vascular biology and pathology
10.1016/j.bcp.2022.115321 · 2022
Guanine nucleotide exchange factors for Rho GTPases (RhoGEFs) as oncogenic effectors and strategic therapeutic targets in metastatic cancer
10.1016/j.cellsig.2023.110749 · 2023
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
10.1016/0092-8674(92)90163-7 · 1992
Regulation of RhoGEF proteins by G12/13-coupled receptors
10.1111/j.1476-5381.2009.00121.x · 2009
G protein-coupled receptor and RhoA-stimulated transcriptional responses: links to inflammation, differentiation, and cell proliferation
10.1124/mol.115.097857 · 2015
Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells
10.1091/mbc.7.11.1679 · 1996
Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3
10.1074/jbc.m104441200 · 2001
Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection
10.1016/j.yjmcc.2014.07.017 · 2014
Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation
10.1161/01.res.82.6.666 · 1998
Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection
10.1016/j.yjmcc.2016.12.008 · 2017
Prevention of RhoA activation and cofilin-mediated actin polymerization mediates the antihypertrophic effect of adenosine receptor agonists in angiotensin II- and endothelin-1-treated cardiomyocytes
10.1007/s11010-013-1832-2 · 2014
Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection
10.1074/jbc.m804036200 · 2008
Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy
10.1161/01.res.0000043282.39776.7c · 2002
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13
10.1126/science.280.5372.2112 · 1998
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13
10.1126/science.280.5372.2109 · 1998
Regulation of RGS-RhoGEFs by Galpha12 and Galpha13 proteins
10.1016/s0076-6879(04)90018-3 · 2004
RhoGEF12 controls cardiac remodeling by integrating G protein- and integrin-dependent signaling cascades
10.1084/jem.20122126 · 2013
G(13)-mediated signaling pathway is required for pressure overload-induced cardiac remodeling and heart failure
10.1161/circulationaha.112.109256 · 2012
Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF
10.1016/j.cellsig.2010.03.006 · 2010
A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors
10.1016/j.molcel.2012.10.018 · 2013
Protein kinase C-alpha signals P115RhoGEF phosphorylation and RhoA activation in TNF-alpha-induced mouse brain microvascular endothelial cell barrier dysfunction
10.1186/1742-2094-8-28 · 2011
Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain
10.1016/j.isci.2025.112753 · 2025
Regulation of RhoA signaling by the cAMP-dependent phosphorylation of RhoGDIalpha
10.1074/jbc.m112.401547 · 2012
Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes
10.1002/j.1460-2075.1996.tb00383.x · 1996
Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif
10.1371/journal.pone.0008045 · 2009
Mechanism of redox-mediated guanine nucleotide exchange on redox-active Rho GTPases
10.1074/jbc.m504768200 · 2005
RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-kappaB activation
10.1016/j.freeradbiomed.2016.12.013 · 2017
Revisited and revised: is RhoA always a villain in cardiac pathophysiology?
10.1007/s12265-010-9192-8 · 2010
RhoA protects the mouse heart against ischemia/reperfusion injury
10.1172/jci44371 · 2011
Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments
10.1161/01.res.85.1.5 · 1999
RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes
10.1152/ajpheart.00692.2004 · 2005
Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation
10.1074/jbc.m300725200 · 2003
Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload
10.1074/jbc.ra118.006123 · 2019
Mechanotransduction: from the cell surface to the nucleus via RhoA
2019
Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells
2015
Cell type specificity of Hippo-YAP signaling in cardiac development and disease
10.1016/j.yjmcc.2025.08.003 · doi-reference
YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution
10.1038/s41467-024-55660-6 · doi-reference
AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis
10.1038/s41598-021-89989-5 · doi-reference
Suppression of myeloid YAP antagonizes adverse cardiac remodeling during pressure overload stress
10.1016/j.yjmcc.2023.05.004 · doi-reference
YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction
10.1371/journal.pbio.3000941 · doi-reference
Abstract P3086: regulation of Rhoa in myeloid cells on remodeling of the infarcted heart
10.1161/res.131.suppl_1.p3086 · doi-reference
Synovial macrophage rhoa protects against osteoarthritis by suppressing YAP/IL-17C mediated chondrocyte senescence
10.1007/s10565-026-10151-w · doi-reference
RhoA deletion in macrophages/microglia aggravates blood-brain barrier disruption after ischemic stroke reperfusion injury by promoting endothelial cell apoptosis and pyroptosis
10.1016/j.nbd.2026.107279 · doi-reference
Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice
10.1186/s12974-021-02292-y · doi-reference
Macrophage/monocyte-specific deletion of Ras homolog gene family member A (RhoA) downregulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts
10.1016/j.healun.2016.08.011 · doi-reference
RhoA signaling in immune cell response and cardiac disease
10.3390/cells10071681 · doi-reference
Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction
10.1161/circresaha.110.223172 · doi-reference
Blockade of fibroblast YAP attenuates cardiac fibrosis and dysfunction through MRTF-A inhibition
10.1016/j.jacbts.2020.07.009 · doi-reference
Loss of Yap/Taz in cardiac fibroblasts attenuates adverse remodelling and improves cardiac function
10.1093/cvr/cvab205 · doi-reference
Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction
10.1172/jci.insight.93187 · doi-reference
Emerging role of YAP/TAZ in vascular mechanotransduction and disease
10.1111/micc.12838 · doi-reference
YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation
10.1172/jci93825 · doi-reference
RhoA accelerates atherosclerosis progression by interacting with Hspa5
10.1038/s41598-025-33741-w · doi-reference
Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity
10.1038/s42003-022-04042-z · doi-reference
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock
10.1038/ncomms7725 · doi-reference
RhoA/Rho-kinase signaling in vascular smooth muscle and endothelium: mechanistic insights and translational implications in hypertension
10.3390/biom15111607 · doi-reference
Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
10.1074/jbc.273.37.24266 · doi-reference
YAP and TAZ in vascular smooth muscle confer protection against hypertensive vasculopathy
10.1161/atvbaha.121.317365 · doi-reference
RhoA/Rho-kinase in the cardiovascular system
10.1161/circresaha.115.306532 · doi-reference
Empagliflozin ameliorates diabetic cardiomyopathy probably via activating AMPK/PGC-1alpha and inhibiting the RhoA/ROCK pathway
10.4239/wjd.v14.i12.1862 · doi-reference
SGLT2 inhibitors and cardiac fibrosis: a comprehensive review
10.1016/j.cpcardiol.2025.103149 · doi-reference
The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling
10.1007/s00109-016-1469-1 · doi-reference
Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats
10.1016/j.cardiores.2007.03.009 · doi-reference
Beneficial effect of intermedin 1-53 in septic shock rats: contributions of Rho kinase and BKCA pathway-mediated improvement in cardiac function
10.1097/shk.0000000000000639 · doi-reference
Endotoxemia engages the RhoA kinase pathway to impair cardiac function by altering cytoskeleton, mitochondrial fission, and autophagy
10.1089/ars.2015.6421 · doi-reference
Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats
10.1093/cvr/cvn095 · doi-reference
Yap overexpression attenuates septic cardiomyopathy by inhibiting DRP1-related mitochondrial fission and activating the ERK signaling pathway
10.1080/10799893.2019.1641822 · doi-reference
The septic heart: current understanding of molecular mechanisms and clinical implications
10.1016/j.chest.2018.08.1037 · doi-reference
Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule
10.1016/j.devcel.2024.04.020 · doi-reference
Parkin deficiency results in accumulation of abnormal mitochondria in aging myocytes
10.4161/cib.24511 · doi-reference
Targeting age-related pathways in heart failure
10.1161/circresaha.119.315889 · doi-reference
Cardiovascular aging and heart failure: JACC review topic of the week
10.1016/j.jacc.2019.06.053 · doi-reference
YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases
10.1172/jci143173 · doi-reference
Yes-associated protein (YAP) facilitates pressure overload-induced dysfunction in the diabetic heart
10.1016/j.jacbts.2019.05.006 · doi-reference
YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload
10.1172/jci150595 · doi-reference