Abstract
Rights: UNKNOWN · https://www.elsevier.com/tdm/userlicense/1.0/ · Source: journal-auto-sync:external:CROSSREF_ISSN
Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
D Akanuma, N Uzawa, M.A Yoshida, A Negishi, T Amagasa, T Ikeuchi
Abstract
Rights: UNKNOWN · https://www.elsevier.com/tdm/userlicense/1.0/ · Source: journal-auto-sync:external:CROSSREF_ISSN
Authors
Institutions
No ROR-resolved institution is linked to this work yet.
Provenance
crossref
Confidence 100%
pubmed
Confidence 98%
unpaywall
Confidence 95%
datacite
No local reference links have been materialized yet.
No local citing links have been materialized yet.
A cell cycle regulator potentially involved in genesis of many tumor types
10.1126/science.8153634 · 1994
Germline p16 mutations in familial melanoma
10.1038/ng0994-15 · 1994
Deletion of p16 and p15 genes in brain tumors
1994
CDKN2 (MTS1) tumor suppressor gene mutations in human tumor cell lines
1995
Frequency of homozygous deletion at p16/CDKN2 in primary human tumours
10.1038/ng1095-210 · 1995
Role of the p16 tumor suppressor gene in cancer
10.1200/jco.1998.16.3.1197 · 1998
Estimates of the worldwide incidence of eighteen major cancer in 1985
10.1002/ijc.2910540413 · 1993
Allelotype of head and neck squamous cell carcinoma
1994
Allelotype of squamous cell carcinoma of the head and neck: fractional allele loss correlates with survival
10.1038/bjc.1995.483 · 1995
Genetic progression model for head and neck cancer: implications for field cancerization
1996
Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer
Confidence 0%
1995
Frequent loss of chromosome 9p21-22 early in head and neck cancer progression
1994
Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment
10.1038/nm0696-682 · 1996
Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas
1996
p16MTS1/CDK4I mutations and concomitant loss of heterozygosity at 9p21-23 are frequent events in squamous cell carcinoma of larynx
10.1038/sj.onc.1201309 · 1997
Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck
1994
Homozygous deletions and loss of expression of the CDKN2 gene occur frequently in head and neck squamous cell carcinoma cell lines but infrequently in primary tumors
10.1002/gcc.2870130204 · 1995
Mutational state of p16/CDKN2 and VHL genes in squamous-cell carcinoma of the oral cavity
1995
High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma
1996
Complex structure and regulation of the p16 (MTS1) locus
1995
A novel p16INK4a transcript
1995
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
10.1016/s0092-8674(00)81400-2 · 1998
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
10.1016/s0092-8674(00)81401-4 · 1998
Multiple type of aberrations in the p16 (INK4a) and the p15 (INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines
10.1002/(sici)1097-0215(19970207)70:4<437::aid-ijc11>3.0.co;2-c · 1997
CDKN2A/p16 is inactivated in most melanoma cell lines
1997
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
1995
Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
1995
p16 gene in uncultured tumors
10.1038/370183a0 · 1994
Frequent inactivation of p16INK4a in oral premalignant lesions
10.1038/sj.onc.1201010 · 1997
No additional external references are available.