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Steven Gerard Clarke
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Stoichiometric methylation of porcine adrenocorticotropin by protein carboxyl methyltransferase requires deamidation of asparagine 25. Evidence for methylation at the α-carboxyl group of atypical l-isoaspartyl residues
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Isoaspartate in peptides and proteins: formation, significance, and analysis
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Ubiquitin-mediated proteolysis in learning and memory
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Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase
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Deamidation of asparagine in a major histocompatibility complex-bound peptide affects T cell recognition but does not explain type B reactivity
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Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins
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Human erythrocyte protein l-isoaspartyl methyltransferase: heritability of basal activity and genetic polymorphism for thermal stability
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Polymorphic forms of the protein l-isoaspartate (d-aspartate) O-methyltransferase involved in the repair of age-damaged proteins
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Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of l-isoaspartyl (d-aspartyl) O-methyltransferase-deficient mice
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Simultaneous stereoinversion and isomerization at specific aspartic acid residues in αA-crystallin from human lens
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Synthesis, aggregation, and neurotoxicity of the Alzheimer’s Aβ1-42 amyloid peptide and its isoaspartyl isomers
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Protein damage and methylation-mediated repair in the erythrocyte
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Deamidation, isomerization
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Folate status and age affect the accumulation of l-isoaspartyl residues in rat liver proteins
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Unresolved referenced work
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Protein isoaspartyl methyltransferase protects from Bax-induced apoptosis
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A highly active protein repair enzyme from an extreme thermophile: the l-isoaspartyl methyltransferase from Thermotoga maritima
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Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein-repair enzyme-deficient mice
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Protein carboxyl methyltransferase facilitates conversion of atypical l-isoaspartyl peptides to normal l-aspartyl peptides
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Partial repair of deamidation-damaged calmodulin by protein carboxyl methyltransferase
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Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins
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Crystal structure of human l-isoaspartyl-O-methyltransferase with S-adenosylhomocysteine at 1.6-Å resolution and modeling of an isoaspartyl-containing peptide at the active site
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Crystal structure of a protein isoaspartyl methyltransferase: a catalyst for protein repair
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Isoaspartate formation at position 23 of amyloid β-peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer’s disease
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Exceptional seed longevity and robust growth: ancient sacred lotus from China
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Crystal structure of human l-isoaspartyl methyltransferase
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High-quality life extension by the enzyme peptide methionine sulfoxide reductase
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Molecular clocks
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Protein deamidation
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The type II isoform of bovine brain protein l-isoaspartyl methyltransferase has an endoplasmic reticulum retention signal (RDEL) at its C-terminus
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d-aspartate content of erythrocyte membrane proteins is decreased in uremia: implications for the repair of damaged proteins
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Complex interactions of the protein l-isoaspartyl methyltransferase and calmodulin revealed with the yeast two-hybrid system
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Do damaged proteins accumulate in Caenorhabditis elegans l-isoaspartate methyltransferase (pcm1) deletion mutants
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Synthetic peptide substrates for the erythrocyte protein carboxyl methyltransferase. Detection of a new site of methylation at isomerized l-aspartyl residues
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Protein repair l-isoaspartyl methyltransferase in plants. Phylogenetic distribution and the accumulation of substrate proteins in aged barley seeds
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The fidelity of protein synthesis: can mischarging by aspartyl-tRNA(Asp) synthetase lead to the formation of isoaspartyl residues in proteins
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Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins
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Alternative splicing of the human isoaspartyl protein carboxyl methyltransferase RNA leads to the generation of a C-terminal-RDEL sequence in isozyme II
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Limited accumulation of damaged proteins in l-isoaspartyl (d-aspartyl) O-methyltransferase-deficient mice
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