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Yongqi He, Xinyuan Hu, Xin-Yu Leng, Li Zhan, Yongjie Cai, Xueqin Chen, Zhaobing Gao, Haiyan Xu, Yushe Yang
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The Role of Voltage-Gated Sodium Channels in Pain Signaling
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Distribution and function of voltage-gated sodium channels in the nervous system
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Voltage-Gated Sodium Channel Dysfunctions in Neurological Disorders
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Provenance
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10.1016/j.ejmech.2025.118326 · 2026
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A-803467, a potent and selective NaV1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
10.1073/pnas.0611364104 · 2007
The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain
10.1016/j.bmc.2018.12.002 · 2019
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10.1016/j.bmcl.2014.06.038 · 2014
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Persistent NaV1.1 and NaV1.6 currents drive spinal locomotor functions through nonlinear dynamics
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Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties
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Multiple NaV1.5 isoforms are functionally expressed in the brain and present distinct expression patterns compared with cardiac NaV1.5
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Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting
10.1016/j.bbamem.2019.05.013 · doi-reference
N-Aroylsulfonamide-Photofragmentation (ASAP)-A Versatile Route to Biaryls
10.1002/ejoc.202100955 · doi-reference
Synthesis and Application of 2,6-Bis(trifluoromethyl)-4-pyridyl Phosphanes: The Most Electron-Poor Aryl Phosphanes with Moderate Bulkiness
10.1002/anie.201104588 · doi-reference
Ammonia-borane as a Catalyst for the Direct Amidation of Carboxylic Acids
10.1021/acs.orglett.1c00591 · doi-reference
Synthesis and anti-endoplasmic reticulum stress activity of N-substituted-2-arylcarbonylhydrazinecarbothioamides
10.1007/s00044-019-02442-1 · doi-reference
Mechanochemical Synthesis of Primary Amides
10.1021/acs.joc.1c02350 · doi-reference
C−H Borylation of Diphenylamines through Adamantane-1-carbonyl Auxiliary by BBr3
10.1021/acs.orglett.0c02552 · doi-reference
Synthesis and Antifungal Activity of 1,2,4-Oxadiazole Derivatives
10.3390/molecules30081851 · doi-reference
Highly Efficient Halide Perovskite Light-Emitting Diodes via Molecular Passivation
10.1002/anie.202100243 · doi-reference
Ligand-Free Copper-Catalyzed Synthesis of Substituted Benzimidazoles, 2-Aminobenzimidazoles, 2-Aminobenzothiazoles, and Benzoxazoles
10.1021/jo901813g · doi-reference
Applications of Lawesson’s reagent in the synthesis of naturally occurring steroids and terpenoids
10.1080/10286020.2017.1295229 · doi-reference
Cyrene as a bio-based solvent for HATU mediated amide coupling
10.1039/c8ob00653a · doi-reference
The role of the methoxy group in approved drugs
10.1016/j.ejmech.2024.116364 · doi-reference
In vitro and in vivo metabolism of 3-Methoxyeticyclidine in human liver microsomes, a zebrafish model, and two human urine samples based on liquid chromatography-high-resolution mass spectrometry
10.1002/dta.3488 · doi-reference
Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties
10.1085/jgp.202313375 · doi-reference
Persistent NaV1.1 and NaV1.6 currents drive spinal locomotor functions through nonlinear dynamics
10.1016/j.celrep.2023.113085 · doi-reference
Enantioselective synthesis of arylmethoxyacetic acid derivatives
10.1016/s0957-4166(03)00023-5 · doi-reference
Gender difference in the pharmacokinetics and metabolism of VX-548 in rats
10.1002/bdd.2387 · doi-reference
Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)
10.1085/jgp.202513778 · doi-reference
Selective Inhibition of NaV1.8 with VX-548 for Acute Pain
10.1056/nejmoa2209870 · doi-reference
Clinical Efficacy and Safety Profile of Suzetrigine: A Novel Non-opioid Analgesic Targeting NaV1.8 Sodium Channel
10.7759/cureus.96054 · doi-reference
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults
10.1093/pm/pnab032 · doi-reference
Recent progress in sodium channel modulators for pain
10.1016/j.bmcl.2014.06.038 · doi-reference
The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain
10.1016/j.bmc.2018.12.002 · doi-reference
A-803467, a potent and selective NaV1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
10.1073/pnas.0611364104 · doi-reference
The effects of A-803467 on cardiac NaV1.5 channels
10.1016/j.ejphar.2015.02.019 · doi-reference
Advances in the discovery of selective NaV1.8 inhibitors for pain management
10.1016/j.ejmech.2025.118326 · doi-reference
Gain-of-function NaV1.8 mutations in painful neuropathy
10.1073/pnas.1216080109 · doi-reference
NaV1.8 expression is not restricted to nociceptors in mouse peripheral nervous system
10.1016/j.pain.2012.04.022 · doi-reference
NaV1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia
10.1093/brain/awae071 · doi-reference
Voltage-Gated Sodium Channel Dysfunctions in Neurological Disorders
10.3390/life13051191 · doi-reference
Distribution and function of voltage-gated sodium channels in the nervous system
10.1080/19336950.2017.1380758 · doi-reference
The Role of Voltage-Gated Sodium Channels in Pain Signaling
10.1152/physrev.00052.2017 · doi-reference
The changing role of non-opioid analgesic techniques in the management of postoperative pain
10.1213/01.ane.0000177099.28914.a7 · doi-reference