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Proliferating
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Targeting proliferating
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Crystal structure
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Structural
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A Transition-State
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Essential
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Targeting cytosolic proliferating cell nuclear antigen
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The bacterial
DNA sliding clamp, β-clamp: structure, interactions, dynamics
and drug discovery
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Extracellular vesicles
deposit PCNA to rejuvenate aged bone marrow-derived
mesenchymal stem cells and slow age-related degeneration
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PCNA: a
silent housekeeper or a potential therapeutic target?
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A cancer-associated
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Structurally distinct
ubiquitin-
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DNA damage response
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Structural
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The discovery of labile methyl esters
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Isolation and characterization of
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Human hepatocellular
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Elevated expression
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PCNA binding
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A million peptide
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Checkpoint
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PCNA binding motifs
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Targeting the “Undruggable”: Small-Molecule Inhibitors
of Proliferating Cell Nuclear Antigen (PCNA) in the Spotlight in Cancer
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DNA Sliding Clamps
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The Anticancer Activity of a First-in-class Small-molecule
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Targeting Proliferating Cell Nuclear
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Identification of small
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A small molecule inhibitor
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enhances DNA double strand break, and sensitizes cancer cells to cisplatin
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Discovery
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Linked-Multiple-Fragment Screen
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Small-molecule
targeting of proliferating cell nuclear antigen chromatin
association inhibits tumor cell growth
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Additive effects of a small molecular PCNA inhibitor PCNA-I1S and
DNA damaging agents on growth inhibition and DNA damage in prostate
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Screening
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the Hsp90alpha inhibitor SNX-2112
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Small
molecule targeting of transcription-replication conflict for
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Transcription-replication
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The potential of PCNA inhibition as a therapeutic strategy
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AOH1996 targets mitochondrial dynamics and metabolism
in leukemic stem cells via mitochondrial PCNA inhibition
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Selective reduction
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Nonpolar
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The Phosphonation
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Thiation with
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1984
Selective
thyroid hormone receptor
beta agonists with oxadiazolone acid isosteres
10.1016/j.bmcl.2020.127465 · 2020
