Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans
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Genetic reduction of IRF5 expression after disease initiation reduces disease in a mouse lupus model by impacting systemic and end-organ pathogenic pathways
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Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease
10.1038/s41467-021-24609-4 · doi-reference
Age-associated B. cells
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Monoallelic IRF5 deficiency in B cells prevents murine lupus
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Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus
10.1073/pnas.1005599107 · doi-reference
IRF-5-mediated inflammation limits CD8+ T cell expansion by inducing HIF-1α and impairing dendritic cell functions during Leishmania infection
10.1371/journal.ppat.1004938 · doi-reference
B7-H1 blockade increases survival of dysfunctional CD8+ T cells and confers protection against Leishmania donovani Infections
10.1371/journal.ppat.1000431 · doi-reference
CD8+ T cell states in human cancer: insights from single-cell analysis
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Phenotypically and functionally unique CD86 expression CD8 T cell subset shapes immune regulation in the tumor microenvironment
10.1016/j.jare.2026.04.006 · doi-reference
TOPK suppresses the CD8+ T cell antitumor immunity via modulation of IRF5 expression
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Transcription factor IRF-5 regulates lipid metabolism and mitochondrial function in murine CD8+ T-cells during viral infection
10.1038/s44318-025-00485-2 · doi-reference
Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naïve vs. effector/memory CD4+ T cells
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The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection
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IRF-5 promotes cell death in CD4 T cells during chronic infection
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IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation
10.1101/2024.08.26.609422 · doi-reference
Critical role of IRF-5 in the development of T helper 1 responses to Leishmania donovani infection
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Plasticity of CD4+ T cell lineage differentiation
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Potential T cell-intrinsic regulatory roles for IRF5 via cytokine modulation in T helper subset differentiation and function
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IRF5 controls plasma cell generation and antibody production via distinct mechanisms depending on the antigenic trigger
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Regulation of age-associated B cells by IRF5 in systemic autoimmunity
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B cell-intrinsic role for IRF5 in TLR9/BCR-induced human B cell activation, proliferation, and plasmablast differentiation
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Myeloid cell-intrinsic IRF5 promotes T cell responses through multiple distinct checkpoints in vivo, and IRF5 immune-mediated disease risk variants modulate these myeloid cell functions
10.4049/jimmunol.1900743 · doi-reference
The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection
10.1016/j.celrep.2024.113795 · doi-reference
IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection
10.1002/jlb.ma0318-136rrr · doi-reference
Frequency of IRF5+ dendritic cells is associated with the TLR7-induced inflammatory cytokine response in SARS-CoV-2 infection
10.1016/j.cyto.2022.156109 · doi-reference
The interferon (IFN) class of cytokines and the IFN regulatory factor (IRF) transcription factor family
10.1101/cshperspect.a028423 · doi-reference
Transcriptional regulation of DC fate specification
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Dendritic cells in cancer immunology and immunotherapy
10.1038/s41577-019-0210-z · doi-reference
The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses
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A critical role for IRF5 in regulating allergic airway inflammation
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Eosinophils and eosinophilic immune dysfunction in health and disease
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Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis
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T cell-intrinsic IRF5 regulates T cell signaling, migration, and differentiation and promotes intestinal inflammation
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STAT5 in human basophils: IL-3 is required for its FcεRI-mediated phosphorylation
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Human basophils secrete IL-3: evidence of autocrine priming for phenotypic and functional responses in allergic disease
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Emerging role of human basophil biology in health and disease
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IRF5 controls both acute and chronic inflammation
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Distinct transcription factor networks control neutrophil-driven inflammation
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Interferon regulatory factor 5 associated neutrophil reprogramming by trained immunity protects against lethal-dose bacterial sepsis
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