Androgen receptor signaling induces CD8(+) T cell dysfunction that is reversed by androgen deprivation therapy in male head and neck squamous cell carcinoma
10.1158/0008-5472.can-25-2384 · doi-reference
Androgen conspires with the CD8(+) T cell exhaustion program and contributes to sex bias in cancer
10.1126/sciimmunol.abq2630 · doi-reference
Androgen receptor-mediated CD8(+) T cell stemness programs drive sex differences in antitumor immunity
10.1016/j.immuni.2022.05.012 · doi-reference
The epidemiology of melanoma in young adults
10.1586/17469872.2013.844465 · doi-reference
Testosterone deficiency is a risk factor for severe COVID-19
10.3389/fendo.2021.694083 · doi-reference
RISING STARS: androgens and immune cell function
10.1530/joe-23-0398 · doi-reference
Glucocorticoid-mediated suppression of effector programming assists the memory transition of virus-specific CD8+ T cells
10.4049/jimmunol.2300513 · doi-reference
Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha
10.4049/jimmunol.168.5.2212 · doi-reference
Epigenetic landscapes reveal transcription factors that regulate CD8(+) T cell differentiation
10.1038/ni.3706 · doi-reference
Divergent effects of a transient corticosteroid therapy on virus-specific quiescent and effector CD8(+) T cells
10.3389/fimmu.2019.01521 · doi-reference
A glucocorticoid-FAS axis controls immune evasion during metastatic seeding
10.1038/s41586-026-10222-2 · doi-reference
Glucocorticoid hormones are both a major circadian signal and major stress signal: how this shared signal contributes to a dynamic relationship between the circadian and stress systems
10.1016/j.yfrne.2017.12.005 · doi-reference
TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion
10.1073/pnas.1905675116 · doi-reference
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction
10.1038/s41586-019-0979-8 · doi-reference
Cutting edge: the orphan nuclear receptor Nr4a1 regulates CD8+ T cell expansion and effector function through direct repression of Irf4
10.4049/jimmunol.1403027 · doi-reference
The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3
10.1038/srep09059 · doi-reference
Cytosporone B is an agonist for nuclear orphan receptor Nur77
10.1038/nchembio.106 · doi-reference
Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells
10.1210/me.2014-1102 · doi-reference
Celastrol-induced Nur77 interaction with TRAF2 alleviates inflammation by promoting mitochondrial ubiquitination and autophagy
10.1016/j.molcel.2017.03.008 · doi-reference
Natural products and synthetic analogs as selective orphan nuclear receptor 4A (NR4A) modulators
10.14670/hh-18-689 · doi-reference
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis
10.1038/ni.2520 · doi-reference
BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustion
10.1126/scitranslmed.abn7336 · doi-reference
Nr4a1 and Nr4a3 reporter mice are differentially sensitive to T cell receptor signal strength and duration
10.1016/j.celrep.2020.108328 · doi-reference
The orphan nuclear receptor NR4A3 is dispensable for resident memory CD8+ T-cell generation
10.1093/immhor/vlaf087 · doi-reference
Early precursors and molecular determinants of tissue-resident memory CD8(+) T lymphocytes revealed by single-cell RNA sequencing
10.1126/sciimmunol.aaz6894 · doi-reference
ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells
10.1172/jci85329 · doi-reference
The circadian clock component RORA increases immunosurveillance in melanoma by inhibiting PD-L1 expression
10.1158/0008-5472.can-23-3942 · doi-reference
Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism
10.1038/nature17412 · doi-reference
RORalpha regulates cholesterol metabolism of CD8(+) T cells for anticancer immunity
10.3390/cancers12071733 · doi-reference
Retinoic acid receptor-related orphan receptor alpha regulates bystander activation of memory CD8(+) T cells
10.3389/fimmu.2025.1647746 · doi-reference
ROR agonist hampers the proliferation and survival of postactivated CD8(+) T cells through the downregulation of cholesterol synthesis-related genes
10.1111/imcb.12406 · doi-reference
LXR/ApoE activation restricts innate immune suppression in cancer
10.1016/j.cell.2017.12.026 · doi-reference
Cholesterol negatively regulates IL-9-producing CD8(+) T cell differentiation and antitumor activity
10.1084/jem.20171576 · doi-reference
LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer
10.1038/s41598-019-56038-1 · doi-reference
Nuclear receptor LXRbeta controls fitness and functionality of activated T cells
10.1084/jem.20201311 · doi-reference
Control of the immune system by oxysterols and cancer development
10.1016/j.coph.2012.07.003 · doi-reference
Oxysterols: modulators of cholesterol metabolism and other processes
10.1152/physrev.2000.80.1.361 · doi-reference
An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
10.1038/383728a0 · doi-reference
1alpha, 25(OH)(2)D(3) reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells
10.1136/jitc-2021-003477 · doi-reference
Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice
10.1073/pnas.0808700106 · doi-reference
