A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
10.1126/science.aay3638 · doi-reference
A wave of Thetis cells imparts tolerance to food antigens early in life
10.1126/science.adp0535 · doi-reference
A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation
10.1038/s41586-022-05089-y · doi-reference
Novel antigen presenting cell imparts Treg-dependent tolerance to gut microbiota
10.1038/s41586-022-05309-5 · doi-reference
Pharmacokinetics, lineage identity, and trafficking of ex vivo expanded polyclonal regulatory T cells in a prospective randomized clinical trial of kidney transplant recipients with allograft inflammation
10.1016/j.ajt.2025.11.011 · doi-reference
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
10.1182/blood-2010-07-293795 · doi-reference
Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models
10.1038/s41467-025-60082-z · doi-reference
Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy
10.1101/2025.07.19.665688 · doi-reference
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance
10.1172/jci139991 · doi-reference
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
10.1126/science.aar3246 · doi-reference
Conversion of pathogenic T cells into functionally stabilized T reg cells for antigen-specific immunosuppression in pemphigus vulgaris
10.1126/scitranslmed.adq9913 · doi-reference
Generating functionally stable and antigen-specific T reg cells from effector T cells for cell therapy of inflammatory diseases
10.1126/scitranslmed.adr6049 · doi-reference
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
10.1073/pnas.1922600117 · doi-reference
Control of Foxp3 stability through modulation of TET activity
10.1084/jem.20151438 · doi-reference
Vitamin C facilitates demethylation of the Foxp3 enhancer in a Tet-dependent manner
10.4049/jimmunol.1502352 · doi-reference
Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective
10.1093/immadv/ltad007 · doi-reference
CAR Treg cells mediate linked suppression and infectious tolerance in islet transplantation in mice
10.1126/scitranslmed.adp6519 · doi-reference
Regulatory T cells expressing CD19-targeted chimeric antigen receptor restore homeostasis in Systemic Lupus Erythematosus
10.1038/s41467-024-46448-9 · doi-reference
Murine CAR19 Tregs suppress acute graft-versus-host disease and maintain graft-versus-tumor responses
10.1172/jci.insight.160674 · doi-reference
CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD
10.1172/jci.insight.136185 · doi-reference
Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
10.1172/jci82771 · doi-reference
Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond
10.1016/j.it.2023.04.005 · doi-reference
Cytokine couture: Designer IL2 molecules for the treatment of disease
10.2147/itt.s500229 · doi-reference
An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice
10.1126/sciimmunol.aba5264 · doi-reference
Next steps in regulatory T cells: Biology and clinical application
10.1016/j.cell.2025.11.035 · doi-reference
A phase 2 randomized trial with autologous polyclonal expanded regulatory T cells in children with new-onset type 1 diabetes
10.1126/scitranslmed.adn2404 · doi-reference
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
10.1126/scitranslmed.aad4134 · doi-reference
The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo-controlled phase 1b trials
10.1038/s41467-024-53384-1 · doi-reference
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
10.1126/scitranslmed.3005265 · doi-reference
Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
10.1016/s2213-8587(13)70113-x · doi-reference
Principles of regulatory T cell function
10.1016/j.immuni.2023.01.004 · doi-reference
Tissue Tregs
10.1146/annurev-immunol-032712-095948 · doi-reference
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
10.1038/nature11132 · doi-reference
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
10.1038/nm.2002 · doi-reference
Regulatory T cell-specific epigenomic region variants are a key determinant of susceptibility to common autoimmune diseases
10.1016/j.immuni.2020.04.006 · doi-reference
Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells
10.1111/imr.12174 · doi-reference
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
10.1016/j.immuni.2012.09.010 · doi-reference
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
10.1016/j.immuni.2025.10.020 · doi-reference
Foxp3 enhancers synergize to maximize regulatory T cell suppressive capacity
10.1084/jem.20202415 · doi-reference
