Abstract
No public abstract is available from the verified source records.
Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureSirui Wang, Ridong Lai, Guofeng Li
Abstract
Authors
Institutions
No ROR-resolved institution is linked to this work yet.
Provenance
crossref
Confidence 100%
pubmed
Confidence 98%
europepmc
Confidence 96%
unpaywall
Confidence 95%
datacite
Confidence 0%
No local reference links have been materialized yet.
No local citing links have been materialized yet.
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease
10.1126/scisignal.adh1641 · 2024
The molecular landscape of inflammation in inflammatory bowel disease (IBD): Targets for precision medicine
10.3390/biomedicines13112738 · 2025
Dysregulated programmed cell death of intestinal epithelial cells in ulcerative colitis: Molecular mechanisms and novel therapeutic interventions (review)
10.3892/ijmm.2025.5671 · 2025
Molecular targets associated with ulcerative colitis and the benefits of atractylenolides-based therapy
10.3389/fphar.2024.1398294 · 2024
Intestinal barrier dysfunction in inflammatory bowel disease: Underpinning pathogenesis and therapeutics
10.1007/s10620-023-08122-w · 2023
TREM1 facilitates nonresponse to anti-TNF-α monoclonal antibodies in colitis via boosting ITCH/TAK1/caspase-8 axis-mediated macrophage pyroptosis
10.1186/s12967-025-07304-6 · 2025
Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis
10.1038/s41467-025-57211-z · 2025
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
10.1126/science.270.5244.2008 · 1995
TAK1 in vascular signaling: ‘Friend or foe’?
10.2147/jir.s458948 · 2024
TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells
10.1042/bcj20220314 · 2022
Bibliometric and visualized analysis on global trends and hotspots of TAK1 in regulated cell death: 1999 to 2024
10.3389/fimmu.2024.1437570 · 2024
Ubiquitination-activated TAB-TAK1-IKK-NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
10.7554/elife.106901 · 2025
Cell type-specific function of TAK1 in innate immune signaling
10.1016/j.it.2013.03.007 · 2013
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis
10.4049/jimmunol.181.2.1143 · 2008
Activation of TGF-β activated kinase 1 promotes colon mucosal pathogenesis in inflammatory bowel disease
10.14814/phy2.13181 · 2017
Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis
10.1371/journal.pone.0004561 · 2009
Macrophage polarization in inflammatory bowel disease
10.1186/s12964-023-01386-9 · 2023
Metabolic programming of macrophage functions and pathogens control
10.1016/j.redox.2019.101198 · 2019
Histological evaluation in ulcerative colitis
10.1093/gastro/gou031 · 2014
The role of macrophage polarization in ulcerative colitis and its treatment
10.1016/j.micpath.2024.107227 · 2025
Macrophages in tissue repair, regeneration, and fibrosis
10.1016/j.immuni.2016.02.015 · 2016
Single-cell and bulk transcriptomics reveals M2d macrophages as a potential therapeutic strategy for mucosal healing in ulcerative colitis
10.1016/j.intimp.2023.110509 · 2023
Identification and experimental validation of immune-related gene PPARG is involved in ulcerative colitis
10.1016/j.bbadis.2024.167300 · 2024
Single-cell RNA-sequencing analysis of colonic lamina propria immune cells reveals the key immune cell-related genes of ulcerative colitis
10.2147/jir.s440076 · 2023
Integrative analysis of single-cell RNA-seq and gut microbiome metabarcoding data elucidates macrophage dysfunction in mice with DSS-induced ulcerative colitis
10.1038/s42003-024-06409-w · 2024
Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation
10.3748/wjg.v24.i1.5 · 2018
The role of enterobacteriaceae in gut microbiota dysbiosis in inflammatory bowel diseases
10.3390/microorganisms9040697 · 2021
A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis
10.1136/gutjnl-2013-304833 · 2014
Gut-derived Enterococcus faecium from ulcerative colitis patients promotes colitis in a genetically susceptible mouse host
10.1186/s13059-019-1879-9 · 2019
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
10.1016/j.cmet.2011.02.018 · 2011
Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
10.3945/jn.109.104638 · 2009
The immunomodulatory functions of butyrate
10.2147/jir.s300989 · 2021
Butyrate inhibits inflammatory responses through NFkappaB inhibition: Implications for Crohn's disease
10.1136/gut.47.3.397 · 2000
Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: Antioxidant action of butyrate
10.1016/j.redox.2018.02.007 · 2018
Early innate immune responses to bacterial LPS
10.1016/j.coi.2016.10.005 · 2017
Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria
10.1038/ajg.2010.281 · 2010
Pattern recognition receptor signaling and cytokine networks in microbial defenses and regulation of intestinal barriers: Implications for inflammatory bowel disease
10.1053/j.gastro.2021.12.288 · 2022
Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation
10.1038/mi.2015.48 · 2016
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
10.1038/s41575-023-00768-1 · 2023
Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
10.1053/j.gastro.2004.12.042 · 2005
Conditional deletion of TAK1 in T cells reveals a pivotal role of TCRαβ+ intraepithelial lymphocytes in preventing lymphopenia-associated colitis
10.1371/journal.pone.0128761 · doi-reference
Enterohemorrhagic Escherichia coli Tir inhibits TAK1 activation and mediates immune evasion
10.1080/22221751.2019.1620589 · doi-reference
Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis
10.1073/pnas.1814705115 · doi-reference
CD137 signaling regulates acute colitis via RALDH2-expressing CD11b-CD103+ DCs
10.1016/j.celrep.2020.02.103 · doi-reference
Discovery of first-in-class TAK1-MKK3 protein-protein interaction (PPI) inhibitor (R)-STU104 for the treatment of ulcerative colitis through modulating TNF-α production
10.1021/acs.jmedchem.1c02198 · doi-reference
GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2
10.1053/j.gastro.2019.02.040 · doi-reference
An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis
10.1126/scitranslmed.aan8162 · doi-reference
RNF186/EPHB2 axis is essential in regulating TNF signaling for colorectal tumorigenesis in colorectal epithelial cells
10.4049/jimmunol.2200229 · doi-reference
E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2
10.1038/s41418-023-01115-2 · doi-reference
TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1
10.1038/s41418-021-00803-1 · doi-reference
Sinapic acid alleviates inflammatory bowel disease (IBD) through localization of tight junction proteins by direct binding to TAK1 and improves intestinal microbiota
10.3389/fphar.2023.1217111 · doi-reference
Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-κB signaling
10.1038/s41420-021-00447-7 · doi-reference
TAK1-TABs complex: A central signalosome in inflammatory responses
10.3389/fimmu.2020.608976 · doi-reference
Autophagy in inflammatory bowel disease: Immunization, etiology, and therapeutic potential
10.3389/fimmu.2025.1543040 · doi-reference
Neutrophil-dependent oxidative stress in ulcerative colitis
10.3164/jcbn.2007003 · doi-reference
Neutrophil extracellular traps sustain inflammatory signals in ulcerative colitis
10.1093/ecco-jcc/jjy215 · doi-reference
Leukotrienes in ulcerative colitis: Results of a multicenter trial of a leukotriene biosynthesis inhibitor, MK-591
10.1053/gast.1997.v112.pm9041233 · doi-reference
IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction
10.1053/j.gastro.2006.08.022 · doi-reference
Apoptosis of crypt epithelial cells in ulcerative colitis
10.1002/(sici)1096-9896(199610)180:2<152::aid-path649>3.0.co;2-y · doi-reference
Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease
10.3748/wjg.v21.i19.5823 · doi-reference
A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation
10.7554/elife.65110 · doi-reference
GM-CSF: A promising target in inflammation and autoimmunity
10.2147/itt.s262566 · doi-reference
The role of Th17 cells in inflammatory bowel disease and the research progress
10.3389/fimmu.2022.1055914 · doi-reference
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells
10.1084/jem.20111453 · doi-reference
Interleukin-1 and related cytokines in the regulation of inflammation and immunity
10.1016/j.immuni.2019.03.012 · doi-reference
Anti-commensal IgG drives intestinal inflammation and type 17 immunity in ulcerative colitis
10.1016/j.immuni.2019.02.006 · doi-reference
Distinct commensals induce interleukin-1β via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury
10.1016/j.immuni.2015.03.004 · doi-reference
IgA in human health and diseases: Potential regulator of commensal microbiota
10.3389/fimmu.2022.1024330 · doi-reference
Dynamic immunoglobulin responses to gut bacteria during inflammatory bowel disease
10.1080/19490976.2019.1626683 · doi-reference
IgA responses to microbiota
10.1016/j.immuni.2018.08.011 · doi-reference
IgG and Fcγ receptors in intestinal immunity and inflammation
10.3389/fimmu.2019.00805 · doi-reference
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis
10.1016/j.immuni.2014.03.012 · doi-reference
Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis
10.1002/ibd.20053 · doi-reference
Impaired luminal control of intestinal macrophage maturation in patients with ulcerative colitis during remission
10.1016/j.jcmgh.2021.06.004 · doi-reference
Regulatory T cells as a therapeutic approach for inflammatory bowel disease
10.1002/eji.202250007 · doi-reference
Mucosal IL-10 and TGF-beta play crucial roles in preventing LPS-driven, IFN-gamma-mediated epithelial damage in human colon explants
10.1172/jci32140 · doi-reference
IFNγ: Signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
10.1038/s41577-018-0029-z · doi-reference
Human neutrophil elastase proteolytic activity in ulcerative colitis favors the loss of function of therapeutic monoclonal antibodies
10.2147/jir.s234710 · doi-reference
IL-22 increases permeability of intestinal epithelial tight junctions by enhancing claudin-2 expression
10.4049/jimmunol.1700152 · doi-reference
IFN-γ, IL-17A, or zonulin rapidly increase the permeability of the blood-brain and small intestinal epithelial barriers: Relevance for neuro-inflammatory diseases
10.1016/j.bbrc.2018.11.021 · doi-reference