Neutrophil extracellular traps in cardiovascular disease: Mechanisms and therapeutic implications (Review)

Itaconate suppresses formation of neutrophil extracellular traps (NETs): Involvement of Hypoxia-Inducible factor 1α (Hif-1α) and heme oxygenase (HO-1)

10.3389/fimmu.2022.864638 · doi-reference

Glycolysis dependent lactate formation in neutrophils: A metabolic link between NOX-dependent and independent NETosis

10.1016/j.bbadis.2019.165542 · doi-reference

Neutrophil Extracellular traps in ST-Segment elevation myocardial infarction: Reduced by tocilizumab and associated with infarct size

10.1016/j.jacadv.2024.101193 · doi-reference

Anthracyclines suppress both NADPH Oxidase-dependent and -independent NETosis in human neutrophils

10.3390/cancers11091328 · doi-reference

H2 Inhibits the formation of neutrophil extracellular traps

10.1016/j.jacbts.2021.11.005 · doi-reference

Colchicine in cardiovascular medicine: Current perspectives on mechanisms and clinical therapeutics

10.1016/j.pharmthera.2026.109053 · doi-reference

Colchicine inhibits NETs and alleviates cardiac remodeling after acute myocardial infarction

10.1007/s10557-022-07326-y · doi-reference

Inhibition of protein arginine deiminase 4 prevents inflammation-mediated heart failure in arthritis

10.26508/lsa.202302055 · doi-reference

Inhibition of peptidyl arginine deiminase-4 protects against myocardial infarction induced cardiac dysfunction

10.1016/j.intimp.2019.106055 · doi-reference

Peptidylarginine deiminase 4-mediated citrullination in human disease: Molecular mechanisms and therapeutic targeting

10.3389/fphar.2026.1854078 · doi-reference

Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis

10.1161/circresaha.114.303312 · doi-reference

Elastase inhibitor AZD9668 treatment prevented progression of experimental abdominal aortic aneurysms

10.1016/j.jvs.2014.07.102 · doi-reference

SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury

10.1016/s0014-2999(03)01298-6 · doi-reference

Neutrophil elastase inhibition ameliorates Endotoxin-induced myocardial injury accompanying degradation of cardiac capillary glycocalyx

10.1097/shk.0000000000001482 · doi-reference

Neutrophil elastase inhibitor (Sivelestat) in the treatment of acute respiratory distress syndrome induced by COVID-19: A multicenter retrospective cohort study

10.1186/s12931-025-03100-4 · doi-reference

Human CRP defends against the toxicity of circulating histones

10.4049/jimmunol.1203181 · doi-reference

Thrombomodulin alfa attenuates the procoagulant effect and cytotoxicity of extracellular histones through the promotion of protein C activation

10.1016/j.thromres.2017.10.019 · doi-reference

Non-anticoagulant heparin attenuates histone-mediated platelet-leukocyte aggregation and neutrophil extracellular trap formation in a canine whole blood model

10.3389/fvets.2026.1778453 · doi-reference

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

10.1182/blood-2013-07-514984 · doi-reference

Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction

10.1186/s40635-015-0072-z · doi-reference

Gene-targeted mice lacking the Trex1 (DNase III) 3′->5'DNA exonuclease develop inflammatory myocarditis

10.1128/mcb.24.15.6719-6727.2004 · doi-reference

Intra- and extracellular degradation of neutrophil extracellular traps by macrophages and dendritic cells

10.4049/jimmunol.1800159 · doi-reference

Engineering actin-resistant human DNase I for treatment of cystic fibrosis

10.1073/pnas.93.16.8225 · doi-reference

Neutrophil extracellular traps directly induce epithelial and endothelial cell death: A predominant role of histones

10.1371/journal.pone.0032366 · doi-reference

Physiology and pathophysiology of mucus and mucolytic use in critically ill patients

10.1186/s13054-025-05286-x · doi-reference

Inhalable dry powder formulations of the commercialised form of Deoxyribonuclease I-a dried alternative for the treatment of cystic fibrosis

10.1016/j.ejps.2026.107463 · doi-reference

Mechanisms of aortic stenosis

10.1016/j.jjcc.2017.11.007 · doi-reference

Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation

10.1016/j.freeradbiomed.2016.01.004 · doi-reference

Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis

10.1161/atvbaha.107.154989 · doi-reference

Deoxyribonuclease is prognostic in patients undergoing transcatheter aortic valve replacement

10.1111/eci.13595 · doi-reference

NETosis is associated with the severity of aortic stenosis: Links with inflammation

10.1016/j.ijcard.2019.03.047 · doi-reference

A Rock and a hard place: Chiseling away at the multiple mechanisms of aortic stenosis

10.1161/circulationaha.117.027776 · doi-reference

Aortic stenosis, atherosclerosis, and skeletal bone: Is there a common link with calcification and inflammation?

10.1093/eurheartj/eht034 · doi-reference

Aortic valve stenosis: From basic mechanisms to novel therapeutic targets

10.1161/atvbaha.119.313067 · doi-reference

Neutrophil proteases promote experimental abdominal aortic aneurysm via extracellular trap release and plasmacytoid dendritic cell activation

10.1161/atvbaha.116.307786 · doi-reference

Inhibition of peptidyl arginine deiminase 4-Dependent neutrophil extracellular trap formation reduces angiotensin II-Induced abdominal aortic aneurysm rupture in mice

10.3389/fcvm.2021.676612 · doi-reference

Neutrophil extracellular traps induce abdominal aortic aneurysm formation by promoting the synthetic and proinflammatory smooth muscle cell phenotype via Hippo-YAP pathway

10.1016/j.trsl.2022.11.010 · doi-reference

Neutrophil extracellular trap-induced ferroptosis promotes abdominal aortic aneurysm formation via SLC25A11-mediated depletion of mitochondrial glutathione

10.1016/j.freeradbiomed.2024.05.036 · doi-reference

Mesenchymal stem cell-derived extracellular vesicles protect against abdominal aortic aneurysm formation by inhibiting NET-induced ferroptosis

10.1038/s12276-023-00986-2 · doi-reference

Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation

10.1016/j.chom.2022.09.004 · doi-reference