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Journal of Medicinal Chemistry - ResearchHub

Journal

Journal of Medicinal Chemistry

0022-2623 · American Chemical Society (ACS)

15 verified public works

Browse all journals →

Discovery of Potent and Selective VHL-Recruiting PROTAC Degraders Targeting EGFR with Improved Developability and Potent Anti-NSCLC Efficacy

2026 · 0 citations

Hsc70-Mediated Targeting Chimeras for Targeted Protein Degradation via Chaperone-Mediated Autophagy

2026 · 0 citations

Brain Penetration Optimization and Anti-neuroinflammation Evaluation of Potent 6-Methyl-7-azaindol-3-yl-quinazoline DYRK1A Inhibitors for Alzheimer’s Disease

2026 · 0 citations

Discovery and Synthesis of Selective Casein Kinase 1δ Degraders for Suppressing Oncogenic NRAS-Mutant Melanoma

2026 · 0 citations

Simultaneous Inhibition of PARP-1 and CK2α by Novel Benzothieno[3,2- d ]pyrimidin-4(1 H )-one Derivatives: A Promising Strategy to Combat Homologous Recombination Deficiency-Independent Tumors and Metastasis

2026 · 0 citations

Discovery of Long-Acting Bifunctional Compounds with Muscarinic M3 and Histamine H1 Receptor Antagonism for the Treatment of Rhinitis

2026 · 0 citations

Discovery of Tetrasubstituted Quinazolin-4(3 H )-ones as Wild-type-sparing, Highly Selective PI3KαH1047R Inhibitors

2026 · 0 citations

Design, Synthesis, and Biological Evaluation of Novel Arylethanone Oxime Ether Derivatives as Potent S1PR1 Agonists for Ulcerative Colitis Therapy

2026 · 0 citations

Fragment-Based Covalent Targeting of Lysines at the Allosteric Latch Site of SHP2

2026 · 0 citations

Impact of Halogen Anisotropy on the Membrane Permeability of Halogenated Drugs

2026 · 0 citations

Second-Generation AOH1996 Analogues with Enhanced Pharmacological Properties for Targeting PCNA

2026 · 0 citations

An Environmentally Sensitive Epidermal Growth Factor Receptor Probe for Turn-On Tumor Imaging and TGF-β1-Mediated Cancer Immunotherapy via the Selective Depletion of TI-Tregs

2026 · 0 citations

Contrastive Learning for Metabolite-Aware Oral Drug Design

2026 · 0 citations

Integrated AI-Driven Multi-Objective Optimization of Sulfamoylbenzamide-Based HBV Capsid Assembly Modulators: Discovery of 11B-6 with Superior Potency and Drug-like Properties

2026 · 0 citations

Discovery of Novel 2-(2-Benzimidazole)-Substituted Tetrahydrofur-ans as Potent and Selective NaV1.8 Inhibitors for the Treatment of Pain

2026 · 0 citations

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